An essential role of PI(4,5)P2 for maintaining the activity of the transient receptor potential canonical (TRPC)4β
The transient receptor potential canonical 4 (TRPC4) channel is a Ca 2+-permeable
nonselective cation channel in mammalian cells and mediates a number of cellular …
nonselective cation channel in mammalian cells and mediates a number of cellular …
[HTML][HTML] Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers
The transient receptor potential canonical (TRPC) 1 channel is widely distributed in
mammalian cells and is involved in many physiological processes. TRPC1 is primarily …
mammalian cells and is involved in many physiological processes. TRPC1 is primarily …
[HTML][HTML] Negative self-regulation of transient receptor potential canonical 4 by the specific interaction with phospholipase C-δ1
Transient receptor potential canonical (TRPC) channels are non-selective calcium-
permeable cation channels. It is suggested that TRPC4β is regulated by phospholipase C …
permeable cation channels. It is suggested that TRPC4β is regulated by phospholipase C …
[HTML][HTML] GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels
The Transient Receptor Potential Canonical 5 (TRPC5) protein forms calcium-permeable
cationic channels that are stimulated by G protein-coupled receptor agonists. The signaling …
cationic channels that are stimulated by G protein-coupled receptor agonists. The signaling …
Close spatio-association of the transient receptor potential canonical 4 (TRPC4) channel with Gαi in TRPC4 activation process
TPRC channels are Ca2+-permeable, nonselective cation channels that are activated by a
wide variety of stimuli, including G protein-coupled receptors (GPCRs). TRPC4 is commonly …
wide variety of stimuli, including G protein-coupled receptors (GPCRs). TRPC4 is commonly …
Molecular determinants of PKA-dependent inhibition of TRPC5 channel
Canonical transient receptor potential (TRPC) channels are Ca2+-permeable, nonselective
cation channels that are widely expressed in numerous cell types. Here, we demonstrate a …
cation channels that are widely expressed in numerous cell types. Here, we demonstrate a …
[HTML][HTML] Molecular determinants of the sensitivity to Gq/11-phospholipase C-dependent gating, Gd3+ potentiation, and Ca2+ permeability in the transient receptor …
X Chen, W Li, AM Riley, M Soliman… - Journal of Biological …, 2017 - ASBMB
Transient receptor potential canonical type 5 (TRPC5) is a Ca 2+-permeable cation channel
that is highly expressed in the brain and is implicated in motor coordination, innate fear …
that is highly expressed in the brain and is implicated in motor coordination, innate fear …
[HTML][HTML] Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels
Canonical transient receptor potential 3 (TRPC3) is a receptor-activated, calcium permeant,
non-selective cation channel. TRPC3 has been shown to interact physically with the N …
non-selective cation channel. TRPC3 has been shown to interact physically with the N …
[HTML][HTML] Potentiation of TRPC5 by protons
M Semtner, M Schaefer, O Pinkenburg… - Journal of Biological …, 2007 - ASBMB
Mammalian members of the classical transient receptor potential channel subfamily (TRPC)
are Ca 2+-permeable cation channels involved in receptor-mediated increases in …
are Ca 2+-permeable cation channels involved in receptor-mediated increases in …
[HTML][HTML] Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC) 4 and TRPC5 channels
The ubiquitous transient receptor potential canonical (TRPC) channels function as non-
selective, Ca 2+-permeable channels and mediate numerous cellular functions. It is …
selective, Ca 2+-permeable channels and mediate numerous cellular functions. It is …