Structural and physiological frontal brain system deficits in patients with schizophrenia are
reviewed quantitatively. We report effect sizes from studies since 1980 that used structural …

Functional neuroimaging and neuropsychological performance indicate a prefrontal
dysfunction in schizophrenia patients. Frontal morphological brain abnormalities are also …

Objective: To highlight the changes in the frontal lobe of the human brain in people with
schizophrenia. Methods: This was a qualitative review of the literature. Results: Many …

Although frontal lobe structural and functional abnormalities have been identified in
schizophrenia, their relationship remains elusive. Because the frontal lobes are both …

A wealth of clinical data indirectly implicate dysfunction of frontal cortex in schizophrenia,
including negative symptoms, the pattern of neuropsychological deficits, and abnormal eye …

OBJECTIVE: Altered prefrontal cortical function has been repeatedly implicated in the
pathophysiology of schizophrenia. Attempts to determine whether this altered function is …

Magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of the
frontal and temporal lobes in schizophrenia patients and healthy controls have proliferated …

This preliminary study focused on the relationship between prefrontal and temporal lobe
MRI measures and neuropsychological performance in chronic schizophrenia. Seventeen …

Background: Studies have reported premorbid as well as postonset social dysfunction in
schizophrenia. This impairment has also been observed to emerge after lesions in the …

Background: Previous structural studies of the frontal lobe in schizophrenia have had
somewhat inconsistent results, but most of them have measured the frontal lobe as a single …