Here, we provide a step-by-step protocol for generating human induced pluripotent stem cell
(hiPSC)-based microglial mouse brain chimeras. In addition, we detail steps for intracerebral …

Microglia are critically involved in complex neurological disorders with a strong genetic
component, such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia …

Microglia, the brain-resident macrophages, exhibit highly dynamic functions in
neurodevelopment and neurodegeneration. Human microglia possess unique features as …

To understand how potential gene manipulations affect in vitro microglia, we provide a set of
short protocols to evaluate microglia identity and function. We detail steps for …

There is increasing genetic evidence for the role of microglia in neurodegenerative
diseases, including Alzheimer's, Parkinson's, and motor neuron disease. Therefore, there is …

Inflammation of the brain and the consequential immunological responses play pivotal roles
in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease …

The ability to generate microglia from human induced pluripotent stem cells (iPSCs)
provides new tools and avenues for investigating the role of microglia in health and disease …

Increasing the neurological-disease toolbox using iPSC-derived microglia | Nature
Medicine Skip to main content Thank you for visiting nature.com. You are using a browser …

Microglia are essential for maintenance of normal brain function, with dysregulation
contributing to numerous neurological diseases. Protocols have been developed to derive …

Background Microglia, the principle immune cells of the brain, play important roles in
neuronal development, homeostatic function and neurodegenerative disease. Recent …