Individuals with Down syndrome (DS) will inevitably develop Alzheimer disease (AD)
neuropathology sometime after middle age, which may be attributable to genes triplicated in …

Down Syndrome (DS) patients develop characteristic Alzheimer's Disease (AD)
neuropathology after their middle age. Prominent neuronal loss has been observed in the …

Abnormal expression of regulator of calcineurin 1 (RCAN1) has been implicated in
Alzheimer's disease (AD) and Down's syndrome (DS). There are two major isoforms of …

ABSTRACT Regulator of calcineurin 1 (RCAN1), a gene identified from the critical region of
Down syndrome, has been implied in pathogenesis of Alzheimer's disease (AD). RCAN1 …

Aging is the largest risk factor for Alzheimer's disease (AD). Patients with Down syndrome
(DS) develop symptoms consistent with early-onset AD, suggesting that overexpression of …

Posttranscriptional regulation of gene expression plays an important role in the maturation,
transport, stability and translation of coding and noncoding RNAs. RNA-binding protein …

Oxidative stress (OS) underlies neuronal dysfunction in many neurodegenerative disorders.
Regulator of Calcineurin 1 (RCAN1 or DSCR1) is a dose-sensitive gene whose …

AD, a devastating neurodegenerative disorder, is the most common cause of dementia in
the elderly. Patients with AD are characterized by three hallmarks of neuropathology …

Regulator of calcineurin 1 (RCAN1/MCIP1/DSCR1) regulates the calmodulin-dependent
phosphatase calcineurin. Because it is located on human chromosome 21, RCAN1 has …

Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably
develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques …