[HTML][HTML] Histone acetylome-wide association study of autism spectrum disorder
The association of histone modification changes with autism spectrum disorder (ASD) has
not been systematically examined. We conducted a histone acetylome-wide association …
not been systematically examined. We conducted a histone acetylome-wide association …
[HTML][HTML] Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
Autism spectrum disorder (ASD) is a phenotypically and genetically heterogeneous
neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown …
neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown …
Epigenetics of autism spectrum disorder: Histone deacetylases
The etiology of autism spectrum disorder (ASD) remains unknown, but gene-environment
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …
[HTML][HTML] Autism genes keep turning up chromatin
JM Lasalle - OA autism, 2013 - ncbi.nlm.nih.gov
Autism-spectrum disorders (ASD) are complex genetic disorders collectively characterized
by impaired social interactions and language as well as repetitive and restrictive behaviors …
by impaired social interactions and language as well as repetitive and restrictive behaviors …
[HTML][HTML] Epigenetics and autism spectrum disorder: Is there a correlation?
AA Eshraghi, G Liu, SIS Kay, RS Eshraghi… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) is the term for a range of development disorders caused by
a combination of genetic and environmental factors (Kubota et al., 2012; Loke et al., 2015; …
a combination of genetic and environmental factors (Kubota et al., 2012; Loke et al., 2015; …
[HTML][HTML] Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures
ASH1L, a histone methyltransferase, is identified as a top-ranking risk factor for autism
spectrum disorder (ASD), however, little is known about the biological mechanisms …
spectrum disorder (ASD), however, little is known about the biological mechanisms …
Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons
HP Shulha, I Cheung, C Whittle, J Wang… - Archives of general …, 2012 - jamanetwork.com
Context Neuronal dysfunction in cerebral cortex and other brain regions could contribute to
the cognitive and behavioral defects in autism. Objective To characterize epigenetic …
the cognitive and behavioral defects in autism. Objective To characterize epigenetic …
[HTML][HTML] The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment
Recent studies implicate chromatin modifiers in autism spectrum disorder (ASD) through the
identification of recurrent de novo loss of function mutations in affected individuals. ASD risk …
identification of recurrent de novo loss of function mutations in affected individuals. ASD risk …
[HTML][HTML] Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder
Integration of emerging epigenetic information with autism spectrum disorder (ASD) genetic
results may elucidate functional insights not possible via either type of information in …
results may elucidate functional insights not possible via either type of information in …
[HTML][HTML] Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder
JM LaSalle - Molecular psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …
outcomes in children with a commonality in deficits in social communication and language …