The insect nephrocyte and the mammalian glomerular podocyte are similar with regard to
filtration, but it remains unclear whether there is an organ or cell type in flies that reabsorbs …

The vertebrate endocytic receptor CUBAM, consisting of three cubilin monomers complexed
with a single amnionless molecule, plays a major role in protein reabsorption in the renal …

Albumin re-uptake is a receptor-mediated pathway located in renal proximal tubuli. There is
increasing evidence of glomerular protein handling by podocytes, but little is known about …

Background The bulk of proteins filtered in the glomeruli are reabsorbed in the proximal
tubule by endocytosis mediated by two multiligand receptors operating in concert, megalin …

Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal
tubule. This process involves two interacting receptors, megalin and cubilin, which form a …

The kidney proximal tubule (PT) elaborates a uniquely high-capacity apical endocytic
pathway to retrieve albumin and other proteins that escape the glomerular filtration barrier …

Cubilin is a peripheral apical membrane receptor for multiple ligands that are taken up in
several absorptive epithelia. Recently, amnionless (AMN) was identified to form a functional …

The multiligand receptors megalin (Lrp2) and cubilin (Cubn) and their endocytic adaptor
protein Dab2 (Dab2) play essential roles in maintaining the integrity of the apical endocytic …

Mammalian podocytes, the key determinants of the kidney's filtration barrier, differentiate
from columnar epithelial cells and several key determinants of apical–basal polarity in the …

Cubilin-and megalin-mediated uptake of albumin in cultured proximal tubule cells of
opossum kidney. Background Reabsorption of albumin from the glomerular filtrate occurs …