Carbazole-based semicarbazones and hydrazones as multifunctional anti-Alzheimer agents
With the aim to combat a multi-faceted neurodegenerative Alzheimer's disease (AD), a
series of carbazole-based semicarbazide and hydrazide derivatives were designed …
series of carbazole-based semicarbazide and hydrazide derivatives were designed …
New classes of carbazoles as potential multi-functional anti-Alzheimer's agents
Multi-Target approach is particularly promising way to drug discovery against Alzheimer's
disease. In the present study, we synthesized a series of compounds comprising the …
disease. In the present study, we synthesized a series of compounds comprising the …
[PDF][PDF] Synthesis, Docking and Evaluation of Novel Pyr-azole Carboxamide Derivatives as Mul-tifunctional Anti-Alzheimer's Agents.(2017) J Med Chem Toxicol 2 (1): 1 …
V Lather - J Med Chem Toxicol, 2017 - researchgate.net
Alzheimer's disease (AD) is a major public health problem. The dual inhibitors of
monoamine oxidase-B (MAO-B) and acetyl cholinesterase (AchE) are reported as effective …
monoamine oxidase-B (MAO-B) and acetyl cholinesterase (AchE) are reported as effective …
Synthesis, biological evaluation and molecular modeling studies of methyl indole-isoxazole carbohydrazide derivatives as multi-target anti-Alzheimer's agents
A Iraji, P Nikfar, M Nazari Montazer, M Karimi… - Scientific Reports, 2024 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects the
elderly population globally and there is an urgent demand for developing novel anti-AD …
elderly population globally and there is an urgent demand for developing novel anti-AD …
Synthesis and AChE inhibitory activity of novel thiazolylhydrazone derivatives
Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is
described together with the impairment of cognitive function. Patients with AD lose the …
described together with the impairment of cognitive function. Patients with AD lose the …
N‐Substituted Arylidene‐3‐(Methylsulfonyl)‐2‐Oxoimidazolidine‐1‐Carbohydrazide as Cholinesterase Inhibitors: Design, Synthesis, and Molecular Docking Study
The development of new enzyme inhibitors in degenerative brain diseases has gained more
attention. Enzyme inhibitors play an effective role in controlling central nervous system …
attention. Enzyme inhibitors play an effective role in controlling central nervous system …
Design, synthesis, and structure–activity relationships of thiazole analogs as anticholinesterase agents for alzheimer's disease
Dementia is a neurological condition commonly correlated with Alzheimer's disease (AD),
and it is seen with many other central nervous system (CNS) disorders. The restricted …
and it is seen with many other central nervous system (CNS) disorders. The restricted …
Design, synthesis, crystal structure, in vitro cytotoxicity evaluation, density functional theory calculations and docking studies of 2-(benzamido) benzohydrazide …
A series of hydrazone derivatives of 2-(benzamido) benzohydrazide was designed,
synthesized, and characterized utilizing FTIR, NMR and UV spectroscopic techniques along …
synthesized, and characterized utilizing FTIR, NMR and UV spectroscopic techniques along …
Synthesis, biological evaluation and molecular modeling study of novel tacrine–carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's …
S Thiratmatrakul, C Yenjai, P Waiwut… - European journal of …, 2014 - Elsevier
New tacrine–carbazole hybrids were developed as potential multifunctional anti-Alzheimer
agents for their cholinesterase inhibitory and radical scavenging activities. The developed …
agents for their cholinesterase inhibitory and radical scavenging activities. The developed …
[HTML][HTML] Design, Synthesis, in vitro biological evaluation and in silico molecular docking study of chloro substituted Benzimidazole-Thiazole hybrid derivatives as …
In order to explore new acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)
inhibitors, a series of benzimidazole-fused-thiazole bearing Schiff base derivatives (1–16) …
inhibitors, a series of benzimidazole-fused-thiazole bearing Schiff base derivatives (1–16) …