Motivation: Determining the methylation state of regions with high copy numbers is
challenging for second-generation sequencing, because the read length is insufficient to …

Cytosine methylation adjacent to adenine, thymine, and cytosine residues but not guanine of
the DNA is distinctively known as non-CpG methylation. This CA/CT/CC methylation …

The tendency of individual CpG sites to be methylated is distinctive, non-random and well-
regulated throughout the genome. We investigated the structural and spatial factors …

DNA CpG methylation is a widespread epigenetic mark in high eukaryotes including
mammals. DNA methylation plays key roles in diverse biological processes such as X …

Motivation DNA methylation can be measured at the single CpG level using sodium bisulfite
conversion of genomic DNA followed by sequencing or array hybridization. Many analytic …

Methylation occurs frequently at 5'-cytosine of the CpG dinucleotides in vertebrate genomes;
however, this epigenetic feature is rarely observed in CpG islands (CGIs) or CpG clusters in …

Motivation Nowadays, epigenetic gene regulations are studied in each part of the biology,
from embryonic development to diseases such as cancers and neurodegenerative …

DNA methylation is an inheritable chemical modification of cytosine, and represents one of
the most important epigenetic events. Computational prediction of the DNA methylation …

DNA is methylated at the dinucleotide CpG in genomes of a wide range of plants and
animals. Among animals, variable patterns of genomic CpG methylation have been …

Motivation: Over 50% of human genes contain CpG islands in their 5′-regions. Methylation
patterns of CpG islands are involved in tissue-specific gene expression and regulation. Mis …