The discovery of the genetic basis of inherited arrhythmias has paved the way for an
improved understanding of arrhythmogenesis in a wide spectrum of life-threatening …

During the last two decades, significant progress has been made in the identification of
genetic defects underlying inherited arrhythmia syndromes, which has provided some …

Life threatening ventricular arrhythmias leading to sudden cardiac death are a major cause
of morbidity and mortality. In the absence of structural heart disease, these arrhythmias …

Cardiac arrhythmias are a major cause of morbidity and mortality. In younger patients, the
majority of sudden cardiac deaths have an underlying Mendelian genetic cause. Over the …

Induced pluripotent stem cells offer the possibility to generate patient-specific stem cell lines
from individuals affected by inherited disorders. Cardiomyocytes differentiated from such …

Fundamental studies of molecular and cellular mechanisms of cardiovascular disease
pathogenesis are required to create more effective and safer methods of their therapy. The …

Despite major efforts by clinicians and researchers, cardiac arrhythmia remains a leading
cause of morbidity and mortality in the world. Experimental work has relied on combining …

There is a need for improved in vitro models of inherited cardiac diseases to better
understand basic cellular and molecular mechanisms and advance drug development. Most …

The use of iPSC-derived cardiomyocytes to study genetic cardiovascular disorders will
enable a deeper and more applicable understanding of the molecular mechanisms of …

Currently available induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) do not
ideally model cellular mechanisms of human arrhythmic disease due to lack of a mature …