Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

L Kappos, R Gold, DH Miller, DG MacManus… - The Lancet, 2008 - thelancet.com
Background Oral fumarate (BG00012) might have dual anti-inflammatory and
neuroprotective effects. Our aim was to assess the efficacy and safety of BG00012 in …

Oral fumaric acid esters for the treatment of active multiple sclerosis: an open‐label, baseline‐controlled pilot study

S Schimrigk, N Brune, K Hellwig… - European journal of …, 2006 - Wiley Online Library
An exploratory, prospective, open‐label study of fumaric acid esters (FAE, Fumaderm®) was
conducted in patients with relapsing–remitting multiple sclerosis (RRMS). The study …

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

R Bomprezzi - Therapeutic advances in neurological …, 2015 - journals.sagepub.com
Multiple sclerosis (MS) shares an immune-mediated origin with psoriasis. Long-term safety
and efficacy data generated in Europe from usage of fumaric acid formulations in the latter …

Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing–remitting multiple sclerosis: subgroup analyses of the DEFINE study

A Bar-Or, R Gold, L Kappos, DL Arnold… - Journal of …, 2013 - Springer
In the double-blind, placebo-controlled, Phase 3 DEFINE study in patients with relapsing–
remitting multiple sclerosis, oral BG-12 (dimethyl fumarate) significantly reduced the …

Efficacy and safety of BG-12 (dimethyl fumarate) and other disease-modifying therapies for the treatment of relapsing–remitting multiple sclerosis: a systematic review …

M Hutchinson, RJ Fox, E Havrdova… - … medical research and …, 2014 - Taylor & Francis
Objective: Currently, direct comparative evidence or head-to-head data between BG-12
(dimethyl fumarate) and other disease-modifying treatments (DMTs) is limited. This study is a …

Long-term safety and efficacy of dimethyl fumarate for up to 13 years in patients with relapsing-remitting multiple sclerosis: Final ENDORSE study results

R Gold, DL Arnold, A Bar-Or, RJ Fox… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: Dimethyl fumarate (DMF) demonstrated favorable benefit–risk in relapsing-
remitting multiple sclerosis (RRMS) patients in phase-III DEFINE and CONFIRM trials, and …

Diroximel fumarate (DRF) in patients with relapsing–remitting multiple sclerosis: Interim safety and efficacy results from the phase 3 EVOLVE-MS-1 study

RT Naismith, JS Wolinsky, A Wundes… - Multiple Sclerosis …, 2020 - journals.sagepub.com
Background: Diroximel fumarate (DRF) is a novel oral fumarate for patients with relapsing–
remitting multiple sclerosis (RRMS). DRF and the approved drug dimethyl fumarate yield …

Dimethyl fumarate: a review of its use in patients with relapsing-remitting multiple sclerosis

CB Burness, ED Deeks - CNS drugs, 2014 - Springer
Dimethyl fumarate (Tecfidera®) is a novel oral therapy that has recently been approved for
the treatment of relapsing forms of multiple sclerosis (MS) and relapsing-remitting MS …

Improving the gastrointestinal tolerability of fumaric acid esters: early findings on gastrointestinal events with diroximel fumarate in patients with relapsing-remitting …

MJ Palte, A Wehr, M Tawa, K Perkin… - Advances in …, 2019 - Springer
Introduction Diroximel fumarate (DRF) is a novel oral fumarate in development for patients
with relapsing forms of multiple sclerosis (MS). Clinical findings from the DRF development …

Safety and efficacy of delayed-release dimethyl fumarate in patients with relapsing-remitting multiple sclerosis: 9 years' follow-up of DEFINE, CONFIRM, and …

R Gold, DL Arnold, A Bar-Or, RJ Fox… - Therapeutic …, 2020 - journals.sagepub.com
Introduction: We report safety and efficacy in patients treated with dimethyl fumarate (DMF)
for~ 9 years in ENDORSE. Lymphocyte analysis data are also reported. Methods: Incidence …