Accumulation of senescent cells during aging contributes to chronic inflammation and age-
related diseases. While senescence is associated with profound alterations of the …

Senescent cells affect many physiological and pathophysiological processes. While select
genetic and epigenetic elements for senescence induction have been identified, the …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory
cytokine release in cells, caused by a variety of stresses. Recent work has convincingly …

Mammalian aging is characterized by the progressive loss of tissue function and increased
risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Senescence is a complex cellular stress response that abolishes proliferative capacity and
generates a unique secretory pattern that is implicated in organismal aging and age-related …

Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

Senescence is a state of enduring growth arrest triggered by sublethal cell damage. Given
that senescent cells actively secrete proinflammatory and matrix-remodeling proteins, their …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …