Although it has been demonstrated that transformed progenitor cell population can
contribute to tumor initiation, factors contributing to this malignant transformation are poorly …

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological
and pathological. Different reports implicate miR-205 in the control of breast stem cell …

Recent studies have demonstrated that miR-205 has a role in both normal development and
cancer, however conflicting reports on its function illustrate the complexity of its regulation …

Dysregulation of epigenetic controls is associated with tumorigenesis in response to
microenvironmental stimuli; however, the regulatory pathways involved in epigenetic …

MicroRNAs (miRNAs) are important regulators of stem and progenitor cell functions. We
previously reported that miR-142 and miR-150 are upregulated in human breast cancer …

MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal
and tumorigenesis. However, the in vivo functions of specific microRNAs in controlling …

Accumulating evidence indicates that a sub-population of cancer cells with stem-like
properties, termed tumor-initiating cells (T-ICs), exist in many different kinds of malignancies …

Abstract miR‐206 is known to suppress breast cancer. However, while it is expressed in
mammary stem cells, its function in such nontumor cells is not well understood. Here, we …

Overexpression of either miR‐302 or miR‐302/367 cluster induces reprogramming of cancer
cells and exerts tumor‐suppressive effects by induction of mesenchymal‐to‐epithelial …

Increasing evidence suggests that lineage specific subpopulations and stem-like cells exist
in normal and malignant breast tissues. Epigenetic mechanisms maintaining this …