Rationale: Goblet cell metaplasia accompanies common pulmonary disorders that are prone
to recurrent viral infections. Mechanisms regulating both goblet cell metaplasia and …

Forkhead box (FOX) proteins are transcriptional factors that regulate various cellular
processes. This minireview provides an overview of FOXA2 functions, with a special …

Chronic airway disorders, including chronic obstructive pulmonary disease (COPD), cystic
fibrosis, and asthma, are associated with persistent pulmonary inflammation and goblet cell …

The airways are lined by several distinct epithelial cells that play unique roles in pulmonary
homeostasis; however, the mechanisms controlling their differentiation in health and …

Bacterial pathogens are a leading cause of lung infections and contribute to acute
exacerbations in patients with chronic respiratory diseases. The innate immune system of …

Rationale: Increased production of mucus is a prominent feature of asthma. IL-13–driven
mucous cell metaplasia is associated with decreased expression of the transcription factor …

After birth, the respiratory tract adapts to recurrent exposures to pathogens, allergens, and
toxicants by inducing the complex innate and acquired immune systems required for …

Foxa2 is a member of the Forkhead family of nuclear transcription factors that is highly
expressed in respiratory epithelial cells of the developing and mature lung. Foxa2 is …

Goblet cell metaplasia and excessive mucus secretion associated with asthma, cystic
fibrosis, and chronic obstructive pulmonary disease contribute to morbidity and mortality …

Foxa1 is a member of the winged helix family of transcription factors that is expressed in
epithelial cells of the conducting airways and in alveolar type II cells of the lung. To …