Oral nirmatrelvir/ritonavir is approved as treatment for acute COVID‐19, but the effect of treatment during acute infection on risk of Long COVID is unknown. We hypothesized that …
Long Covid–the disease encompassing the post-acute sequelae of SARS-CoV-2 (PASC)— affects millions of people around the world. Prevention of PASC is an urgent public health …
AA Butt, P Yan, OS Shaikh, VB Talisa… - The Journal of …, 2024 - academic.oup.com
Objective To determine the association of nirmatrelvir/ritonavir (NMV/r) with hospitalization or death within 30 days as compared with untreated controls previously uninfected and …
H Wang, Y Wei, CT Hung, G Lin, X Jiang… - The Lancet Infectious …, 2024 - thelancet.com
Background Studies have established the short-term efficacy of nirmatrelvir–ritonavir in managing COVID-19, yet its effect on post-COVID-19 condition, especially in patients …
J Hammond, RJ Fountaine, C Yunis… - … England Journal of …, 2024 - Mass Medical Soc
Background Nirmatrelvir in combination with ritonavir is an antiviral treatment for mild-to- moderate coronavirus disease 2019 (Covid-19). The efficacy of this treatment in patients …
J Hammond, H Leister-Tebbe, A Gardner… - … England Journal of …, 2022 - Mass Medical Soc
Background Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (Mpro) inhibitor with potent pan–human-coronavirus activity in …
Background: Efforts to understand the impact of SARS-CoV-2 variants, vaccine status, and treatment on the development and persistence of Long COVID have intensified. Methods …
S Congdon, Z Narrowe, N Yone, J Gunn, Y Deng… - Scientific reports, 2023 - nature.com
We conducted a retrospective cohort study to assess whether treatment with nirmatrelvir/ritonavir was associated with a reduced risk of long COVID. We enrolled 500 …
Background: In the EPIC-HR trial, nirmatrelvir plus ritonavir led to an 88% reduction in hospitalization or death among unvaccinated outpatients with early COVID-19. Clinical …