Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants

L Li, M Gao, P Jiao, S Zu, Y Deng, D Wan, Y Cao… - Cell & Bioscience, 2022 - Springer
Background Neutralizing antibodies are approved drugs to treat coronavirus disease-2019
(COVID-19) patients, yet mutations in severe acute respiratory syndrome coronavirus (SARS …

MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 Variants

S Lee, S Jang, J Kang, SB Park, YW Han… - Frontiers in …, 2021 - frontiersin.org
Since the coronavirus disease outbreak in 2019, several antibody therapeutics have been
developed to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

A potent and protective human neutralizing antibody against SARS-CoV-2 variants

S Shan, CK Mok, S Zhang, J Lan, J Li, Z Yang… - Frontiers in …, 2021 - frontiersin.org
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to
emerge and spread around the world, antibodies and vaccines to confer broad and potent …

An antibody cocktail with broadened mutational resistance and effective protection against SARS-CoV-2

C Sun, H Chi, F Yuan, J Li, J Yang, A Zheng… - Science China Life …, 2023 - Springer
Neutralizing antibodies have been proven to be highly effective in treating mild and
moderate COVID-19 patients, but continuous emergence of SARS-CoV-2 variants poses …

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

L Liu, RG Casner, Y Guo, Q Wang, S Iketani, JFW Chan… - bioRxiv, 2023 - biorxiv.org
SUMMARY SARS-CoV-2 continues to evolve and evade most existing neutralizing
antibodies, including all clinically authorized antibodies. We have isolated and …

Pre-Clinical Development of a Potent Neutralizing Antibody MW3321 With Extensive SARS-CoV-2 Variants Coverage

W Jiang, Z Zhang, Y Zhu, B Chen, C Gu, Z Liu… - Frontiers in …, 2022 - frontiersin.org
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, several variants
of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged and …

Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance

J Zou, L Li, P Zheng, W Liang, S Hu… - The Journal of …, 2022 - Am Soc Clin Investig
Many SARS-CoV-2 neutralizing antibodies (nAbs) lose potency against variants of concern.
In this study, we developed 2 strategies to produce mutation-resistant antibodies. First, a …

A potent SARS-CoV-2 neutralizing antibody recognizing a conserved epitope with broad mutant variant and SARS-CoV activity

AJ Pelzek, S Ebtehaj, J Lulo, L Zhang, O Balduf… - bioRxiv, 2022 - biorxiv.org
COVID-19 is the deadliest respiratory virus pandemic since 1918 and the latest of several
coronavirus epidemics and pandemics in recent years. Despite the unprecedented …

Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern

IA Favorskaya, DV Shcheblyakov… - Frontiers in …, 2022 - frontiersin.org
Virus-neutralizing antibodies are one of the few treatment options for COVID-19. The
evolution of SARS-CoV-2 virus has led to the emergence of virus variants with reduced …

SARS‐CoV‐2 neutralizing antibody epitopes are overlapping and highly mutated which raises the chances of escape variants and requires development of broadly …

J Joseph, S Darpe, G Kulkarni… - … : Structure, Function, and …, 2023 - Wiley Online Library
The rapid adaptation of SARS‐CoV‐2 within the host species and the increased viral
transmission triggered the evolution of different SARS‐CoV‐2 variants. Though numerous …