In the premature infant, exposure of the incompletely vascularized retina to increased
oxygen tension can result in the development of a blinding disease, retinopathy of …

Retinopathy of prematurity (ROP) is initiated by hyperoxia–induced obliteration of newly
formed blood vessels in the retina of the premature newborn. We propose that vessel …

Vitamin E is used to ameliorate retinopathy of prematurity, but little is known about baseline
vitamin E levels in retinas of premature infants or the effect of vitamin E supplementation on …

The immature retinas of preterm neonates are susceptible to insults that disrupt
neurovascular growth, leading to retinopathy of prematurity. Suppression of growth factors …

Spindle cells in the hyperoxygenated, avascular, vanguard retina are proposed to be the
peripheral inducers of the neovascularization associated with retinopathy of prematurity …

Mechanisms and Management of Retinopathy of Prematurity | New England Journal of Medicine
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The effect of high-dosage E treatment (Rx) initiated at the stage of 3-plus active disease
(target serum E levels, 5-6 mg/dl) was evaluated by a standardized scoring system of visual …

Oxygen administration to premature infants suppresses retinal VEGF expression and results
in the catastrophic vessel loss associated with retinopathy of prematurity. A study …

Retinopathy of prematurity1(ROP) has been at the nexus of a progressive understanding of
neovascularisation, in large part because of the mouse model of oxygen-induced …

Retinopathy of prematurity is marked by the proliferative vascularization of the retina in
preterm babies. An understanding of the molecular pathogenesis of ROP provides the basis …