Frequent allelic losses of chromosome 3p in lung cancer have been reported in a number of
studies, and we previously demonstrated that 3p21. 3 is one of the common regions of …

The 3p deletion was first noted by cytogenetic analysis and was later confirmed by several
independent studies using restriction fragment length polymorphism (RFLP) probes. As an …

Cytogenetic and loss of heterozygosity (LOH) studies have demonstrated that deletions of
chromosome 3p occur at a high frequency in all forms of lung cancer. To clarify the role of 3p …

Non-small-cell lung cancer is the leading cause of cancer death for men and women in the
industrialized nations. Identification of regions for genes involved in its pathogenesis has …

We analyzed the pattern of allelic loss on chromosome 9 in 40 primary human non-small cell
lung cancers including 16 squamous cell, 18 adeno-, and 6 large cell carcinomas. Using 24 …

To understand the molecular pathogenesis of human lung cancer, we analyzed allelic
deletions on the long arm of chromosome 16 by PCR amplification of microsatellite markers …

Frequent losses of heterozygosity observed at several chromosomal loci in primary lung
cancers have indicated the existence of several tumor suppressor genes associated with …

The high incidence of loss of heterozygosity (LOH) on chromosome 18q in advanced non-
small cell lung carcinomas indicates the presence of tumor suppressor gene (s) on this …

Molecular, functional, and clinical analyses strongly suggest that chromosome segment
11p15. 5 contains a gene involved in lung cancer pathogenesis. The critical region of allele …

The relatively frequent loss of heterozygosity at loci on the short arm of chromosome 11 in
human lung cancers has suggested the presence of a putative tumor suppressor gene. For …