A comprehensive molecular interaction map for rheumatoid arthritis

G Wu, L Zhu, JE Dent, C Nardini - PLoS One, 2010 - journals.plos.org
Background Computational biology contributes to a variety of areas related to life sciences
and, due to the growing impact of translational medicine-the scientific approach to medicine …

[HTML][HTML] Computational systems biology approach for the study of rheumatoid arthritis: from a molecular map to a dynamical model

V Singh, M Ostaszewski, GD Kalliolias… - Genomics and …, 2018 - ncbi.nlm.nih.gov
In this work we present a systematic effort to summarize current biological pathway
knowledge concerning Rheumatoid Arthritis (RA). We are constructing a detailed molecular …

RA-map: building a state-of-the-art interactive knowledge base for rheumatoid arthritis

V Singh, GD Kalliolias, M Ostaszewski, M Veyssiere… - Database, 2020 - academic.oup.com
Rheumatoid arthritis (RA) is a progressive, inflammatory autoimmune disease of unknown
aetiology. The complex mechanism of aetiopathogenesis, progress and chronicity of the …

A cytokine protein-protein interaction network for identifying key molecules in rheumatoid arthritis

V Panga, S Raghunathan - PloS one, 2018 - journals.plos.org
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the synovial joints. Though
the current RA therapeutics such as disease-modifying antirheumatic drugs (DMARDs) …

A systems approach to rheumatoid arthritis

S You, CS Cho, I Lee, L Hood, D Hwang, WU Kim - PloS one, 2012 - journals.plos.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily attacks synovial
joints. Despite the advances in diagnosis and treatment of RA, novel molecular targets are …

A mechanistic cellular atlas of the rheumatic joint

N Zerrouk, S Aghakhani, V Singh, F Augé… - Frontiers in Systems …, 2022 - frontiersin.org
Rheumatoid Arthritis (RA) is an autoimmune disease of unknown aetiology involving
complex interactions between environmental and genetic factors. Its pathogenesis is …

" A System Biology" Approach to Bioinformatics and Functional Genomics in Complex Human Diseases: Arthritis

MG Attur, MN Dave, K Tsunoyama, M Akamatsu… - Current issues in …, 2002 - mdpi.com
Human and other annotated genome sequences have facilitated generation of vast amounts
of correlative data, from human/animal genetics, normal and disease-affected tissues from …

Implying Analytic Measures for Unravelling Rheumatoid Arthritis Significant Proteins Through Drug–Target Interaction

S Singh, JJ Vennila, VP Snijesh, G George… - Interdisciplinary Sciences …, 2016 - Springer
Rheumatoid arthritis (RA) is a systemic autoimmune and inflammatory disease that mainly
alters the synovial joints and ultimately leads to their destruction. The involvement of the …

Immune cell-specific and common molecular signatures in rheumatoid arthritis through molecular network approaches

B Comertpay, E Gov - Biosystems, 2023 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disorder and common symptom of RA is chronic
synovial inflammation. The pathogenesis of RA is not fully understood. Therefore, we aimed …

Systems biology approach delineates critical pathways associated with disease progression in rheumatoid arthritis

SK Srimadh Bhagavatham, SK Pulukool… - Journal of …, 2023 - Taylor & Francis
Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease leading to
inflammation, cartilage cell death, synoviocyte proliferation, and increased and impaired …