Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair
host resistance to intracellular bacteria in mice. However, the precise role of type I IFN …

Type I interferons are important in regulating immune responses to pathogens and tumors.
All interferons are considered to signal via the heterodimeric IFNAR1-IFNAR2 complex, yet …

The interaction of IFN-β with its receptor IFNAR1 (interferon α/β receptor subunit 1) is vital for
host-protective anti-viral and anti-proliferative responses, but signaling via this interaction …

Type I interferon (IFN-α/β) is a fundamental antiviral defense mechanism. Mouse models
have been pivotal to understanding the role of IFN-α/β in immunity, although validation of …

IFN-β-specific signaling via a unique IFNAR1 interaction | Nature Immunology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

During viral infections, type I interferons (IFN) are induced and play a key role in
counteracting initial viral spread. Twelve different human IFNα subtypes exist that bind the …

Alpha and beta interferons (IFN-α and IFN-β) are multifunctional cytokines that exhibit
differential activities through a common receptor composed of the subunits IFNAR1 and …

General interest in the biological functions of IFN type I in Mycobacterium tuberculosis (Mtb)
infection increased after the recent identification of a distinct IFN gene expression signature …

The type I interferon (IFN) receptor plays a key role in innate immunity against viral and
bacterial infections. Here, we show by intramolecular Förster resonance energy transfer …

Type I interferons activate cellular responses by forming a ternary complex with two receptor
components, IFNAR1 and IFNAR2. While the binding of the IFNAR2 receptor to interferon is …