Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group …

RE Pratley, M Nauck, T Bailey, E Montanya, R Cuddihy… - The Lancet, 2010 - thelancet.com
Background Agonists of the glucagon-like peptide-1 (GLP-1) receptor provide
pharmacological levels of GLP-1 activity, whereas dipeptidyl peptidase-4 (DPP-4) inhibitors …

One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with …

R Pratley, M Nauck, T Bailey… - … journal of clinical …, 2011 - Wiley Online Library
Aim: The aim of this study was to compare the efficacy and safety of once‐daily human
glucagon‐like peptide‐1 analogue liraglutide with dipeptidyl peptidase‐4 inhibitor …

Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial

A Garber, R Henry, R Ratner, PA Garcia-Hernandez… - The Lancet, 2009 - thelancet.com
Background New treatments for type 2 diabetes mellitus are needed to retain insulin–
glucose coupling and lower the risk of weight gain and hypoglycaemia. We aimed to …

Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+ SU): a randomised …

D Russell-Jones, A Vaag, O Schmitz, BK Sethi, N Lalic… - Diabetologia, 2009 - Springer
Aims/hypothesis The aim of the study was to compare the efficacy and safety of liraglutide in
type 2 diabetes mellitus vs placebo and insulin glargine (A21Gly, B31Arg, B32Arg human …

Long‐term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2‐year results from the LEAD‐2 …

M Nauck, A Frid, K Hermansen… - Diabetes, Obesity …, 2013 - Wiley Online Library
Aims To investigate efficacy and safety of dual therapy with liraglutide and metformin in
comparison to glimepiride and metformin, and metformin monotherapy over 2 years in …

Efficacy and safety of liraglutide versus placebo added to basal insulin analogues (with or without metformin) in patients with type 2 diabetes: a randomized, placebo …

A Ahmann, HW Rodbard, J Rosenstock… - Diabetes, Obesity …, 2015 - Wiley Online Library
Aim To confirm the superiority, compared with placebo, of adding liraglutide to pre‐existing
basal insulin analogue±metformin in adults with inadequately controlled type 2 diabetes …

Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in …

M Nauck, A Frid, K Hermansen, NS Shah… - Diabetes …, 2009 - Am Diabetes Assoc
OBJECTIVE—The efficacy and safety of adding liraglutide (a glucagon-like peptide-1
receptor agonist) to metformin were compared with addition of placebo or glimepiride to …

Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 …

RE Pratley, MA Nauck, T Bailey, E Montanya… - Diabetes …, 2012 - Am Diabetes Assoc
OBJECTIVE To assess the efficacy and safety of switching from sitagliptin to liraglutide in
metformin-treated adults with type 2 diabetes. RESEARCH DESIGN AND METHODS In an …

Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non …

KM Dungan, ST Povedano, T Forst, JGG González… - The Lancet, 2014 - thelancet.com
Background Dulaglutide and liraglutide, both glucagon-like peptide-1 (GLP-1) receptor
agonists, improve glycaemic control and reduce weight in patients with type 2 diabetes. In a …

Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)

JB Buse, J Rosenstock, G Sesti, WE Schmidt… - The Lancet, 2009 - thelancet.com
Background Unlike most antihyperglycaemic drugs, glucagon-like peptide-1 (GLP-1)
receptor agonists have a glucose-dependent action and promote weight loss. We compared …