Type 2 diabetes is associated with numerous long-term complications. This study aims to
investigate whether impaired function of tissue-resident multipotent cells play role in …

The widespread epidemic of obesity and type 2 diabetes (T2D), suggests that both disorders
are closely linked. Several pre-clinical and clinical studies have showed that adipose …

Cell therapy is thought to be a possible approach for treatment of diabetes. Cells with the
ability to differentiate into insulin-producing cells (IPCs) would provide an unlimited source …

Background aims Adipose-derived stem cells (ASCs) represent an important source of cell
therapy to treat diabetic complications. However, hyperglycemia may alter several cellular …

Type 2 diabetes mellitus (T2DM) is mainly characterized by insulin resistance (IR) and
impaired insulin secretion. The chronic inflammatory process contributed to IR and could …

Stem cells with the ability to differentiate into insulin-producing cells (IPCs) are becoming the
most promising therapy for diabetes mellitus and reduce the major limitations of availability …

To assess the potential therapeutic effects of adipose tissue-derived mesenchymal stem
cells (ASCs) for the treatment of type 2 diabetes (T2D), we compared the phenotype and …

Mesenchymal stem cells (MSC) from mouse bone marrow were shown to adopt a pancreatic
endocrine phenotype in vitro and to reverse diabetes in an animal model. MSC from human …

Background Long-term diabetes-associated complications are the major causes of morbidity
and mortality in individuals with diabetes. These diabetic complications are closely linked to …

Aims/hypothesis Autologous progenitor cells represent a promising option for regenerative
cell-based therapies. Nevertheless, it has been shown that ageing and cardiovascular risk …