Exploring the pharmacogenomics knowledge base (PharmGKB) for repositioning breast cancer drugs by leveraging Web ontology language (OWL) and …

Q Zhu, CUI Tao, F Shen, CG Chute - Biocomputing 2014, 2014 - World Scientific
Computational drug repositioning leverages computational technology and high volume of
biomedical data to identify new indications for existing drugs. Since it does not require costly …

Transcriptomic-guided drug repositioning supported by a new bioinformatics search tool: geneXpharma

B Turanli, G Gulfidan, KY Arga - OMICS: A Journal of Integrative …, 2017 - liebertpub.com
Drug repositioning is an innovative approach to identify new therapeutic indications for
existing drugs. Drug repositioning offers the promise of reducing drug development …

DrugSig: A resource for computational drug repositioning utilizing gene expression signatures

H Wu, J Huang, Y Zhong, Q Huang - PloS one, 2017 - journals.plos.org
Computational drug repositioning has been proved as an effective approach to develop new
drug uses. However, currently existing strategies strongly rely on drug response gene …

Drug repositioning of herbal compounds via a machine-learning approach

E Kim, A Choi, H Nam - BMC bioinformatics, 2019 - Springer
Background Drug repositioning, also known as drug repurposing, defines new indications
for existing drugs and can be used as an alternative to drug development. In recent years …

A systematic framework for drug repositioning from integrated omics and drug phenotype profiles using pathway‐drug network

E Jadamba, M Shin - BioMed research international, 2016 - Wiley Online Library
Drug repositioning offers new clinical indications for old drugs. Recently, many
computational approaches have been developed to repurpose marketed drugs in human …

Biomedical data and computational models for drug repositioning: a comprehensive review

H Luo, M Li, M Yang, FX Wu, Y Li… - Briefings in …, 2021 - academic.oup.com
Drug repositioning can drastically decrease the cost and duration taken by traditional drug
research and development while avoiding the occurrence of unforeseen adverse events …

DMAP: a connectivity map database to enable identification of novel drug repositioning candidates

H Huang, T Nguyen, S Ibrahim, S Shantharam, Z Yue… - BMC …, 2015 - Springer
Background Drug repositioning is a cost-efficient and time-saving process to drug
development compared to traditional techniques. A systematic method to drug repositioning …

Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug

HS Lee, T Bae, JH Lee, DG Kim, YS Oh, Y Jang… - BMC systems …, 2012 - Springer
Background The process of drug discovery and development is time-consuming and costly,
and the probability of success is low. Therefore, there is rising interest in repositioning …

Computational drug repositioning through heterogeneous network clustering

C Wu, RC Gudivada, BJ Aronow, AG Jegga - BMC systems biology, 2013 - Springer
Background Given the costly and time consuming process and high attrition rates in drug
discovery and development, drug repositioning or drug repurposing is considered as a …

Computational drug repositioning: from data to therapeutics

MR Hurle, L Yang, Q Xie, DK Rajpal… - Clinical …, 2013 - Wiley Online Library
Traditionally, most drugs have been discovered using phenotypic or target‐based screens.
Subsequently, their indications are often expanded on the basis of clinical observations …