BACKGROUND: Allergic rhinitis is characterized by mast cell degranulation induced by
antigen cross-linking of IgE. It has been proposed that some patients with rhinitis show nasal …

Background Increasing evidence is available about the presence of increased serum
concentration of immunoglobulin (Ig) free light chains (FLCs) in both atopic and non‐atopic …

Allergic diseases have become a serious global health problem in the developed world. IgE
interacting with its high‐affinitiy receptor FcɛRI is considered a major contributing factor to …

The observation that only 50% of patients with adult asthma manifest atopy indicates that
other inflammatory mechanisms are likely involved in producing the characteristic features of …

Background In perennial allergic rhinitis, patients are almost daily exposed to aeroallergens.
This ongoing allergic reaction results in increased sensitivity to allergens and non‐specific …

Cross-linking of allergen specific IgE bound to the high affinity IgE receptor (FC epsilonRI)
on the surface of mast cells with multivalent allergens results in the release of both pre …

Background Allergen challenge in some patients with respiratory allergy is followed by an
early and a late reaction. Objective To evaluate the duration of mediator release and …

An increase in immunoglobulin free light chains (FLC) was recently described in several
pathological conditions, including asthma. FLC pathology is classically associated with …

BACKGROUND: It is well documented that the chemokine that is regulated upon activation,
normal T expressed and presumably secreted, RANTES, is produced by macrophages …

BACKGROUND: Increasing evidence suggsts adhesion molecules and cytokines in patients
with inflamatory airway diseases are involved in steps of entrapment and migration of …