Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However,
there are a number of emerging experimental variables that alter CR responses. We …

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …

Background Calorie restriction (CR) is the only intervention known to extend lifespan in a
wide range of organisms, including mammals. However, the mechanisms by which it …

Caloric restriction (CR) mitigates many detrimental effects of aging and prolongs life span.
CR has been suggested to increase mitochondrial biogenesis, thereby attenuating age …

Caloric restriction, a reduction in calorie intake without malnutrition, retards age-related
degeneration and extends lifespan in several organisms. CR induces multiple changes, yet …

Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition,
decelerates the rate of aging and the development of age-related diseases. CR has been …

The impact of chronic caloric restriction (CR) on health and survival is complex with poorly
understood underlying molecular mechanisms. A recent study in mice addressing the diets …

Diet is the only known intervention which has been conclusively shown to extend life span. It
can be argued the key role diet has to play in the aging process came to prominence as a …

Caloric restriction (CR) and down‐regulation of the insulin/IGF pathway are the most robust
interventions known to increase longevity in lower organisms. However, little is known about …

Caloric restriction (CR) extends lifespan and delays the onset of age-related disorders in
diverse species. Metabolic regulatory pathways have been implicated in the mechanisms of …