Microcystin analysis in human sera and liver from human fatalities in Caruaru, Brazil 1996

M Yuan, WW Carmichael, ED Hilborn - Toxicon, 2006 - Elsevier
In 1996, an extensive exposure of Brazilian hemodialysis patients at a dialysis center, using
a municipal water supply water contaminated with cyanotoxins, provided the first evidence …

First identification of the hepatotoxic microcystins in the serum of a chronically exposed human population together with indication of hepatocellular damage

J Chen, P Xie, L Li, J Xu - Toxicological sciences, 2009 - academic.oup.com
Hepatotoxic microcystins (MCs) are the most commonly reported cyanotoxins in eutrophic
freshwaters. In 1996, human intoxications by MCs caused deaths of 76 patients at Caruaru …

Determination of microcystins in biological samples by matrix solid-phase dispersion and liquid chromatography–mass spectrometry

MJ Ruiz, AM Cameán, IM Moreno, Y Picó - Journal of Chromatography A, 2005 - Elsevier
A method for the detection and quantification of the microcystins (MCs)—MC-LR, MC-RR
and MC-YR—in biological samples by matrix solid-phase dispersion (MSPD) has been …

Reliable and sensitive method for determination of microcystins in complicated matrices by frit‐fast atom bombardment liquid chromatography/mass spectrometry

F Kondo, Y Ikai, H Oka, H Matsumoto… - Natural …, 1995 - Wiley Online Library
A reliable and sensitive method for determination of hepatotoxic microcystins in complicated
matrices by frit‐fast atom bombardment liquid chromatography/mass spectrometry (Frit‐FAB …

Human intoxication by microcystins during renal dialysis treatment in Caruaru—Brazil

SMFO Azevedo, WW Carmichael, EM Jochimsen… - Toxicology, 2002 - Elsevier
In February 1996, an outbreak of illness occurred at a hemodialysis clinic in Caruaru,
Pernambuco State—Brazil. At this clinic 116 (89%) of 131 patients experienced visual …

Serologic evaluation of human microcystin exposure

ED Hilborn, WW Carmichael, RM Soares… - Environmental …, 2007 - Wiley Online Library
Microcystins are among the most commonly detected toxins associated with cyanobacteria
blooms worldwide. Two episodes of intravenous microcystin exposures occurred among …

Sublethal exposure from microcystins to renal insufficiency patients in Rio de Janeiro, Brazil

RM Soares, M Yuan, JC Servaites… - Environmental …, 2006 - Wiley Online Library
In November 2001, a cyanobacterial bloom dominated by Microcystis and Anabaena
occurred in the Funil Reservoir and the Guandu River, both of which supply drinking water to …

A simple colorimetric method to detect biological evidence of human exposure to microcystins

ED Hilborn, WW Carmichael, M Yuan, SMFO Azevedo - Toxicon, 2005 - Elsevier
Toxic cyanobacteria are contaminants of surface waters worldwide. Microcystins are some of
the most commonly detected cyanotoxins. Biological evidence of human exposure may be …

Optimization of intracellular microcystin extraction for their subsequent analysis by high-performance liquid chromatography

M Barco, LA Lawton, J Rivera, J Caixach - Journal of Chromatography A, 2005 - Elsevier
Microcystins are a family of heptapeptide hepatotoxins produced by some genera of
cyanobacteria. These toxins have been responsible for the illness and death of both animals …

[HTML][HTML] Microcystins in South American aquatic ecosystems: Occurrence, toxicity and toxicological assays

FA Dörr, E Pinto, RM Soares - Toxicon, 2010 - Elsevier
The acute poisoning of chronic renal patients during hemodialysis sessions in 1996 in
Caruaru City (Pernambuco State, Brazil) stimulated an intensive search for the cause of this …