Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD

N Ledo, YA Ko, ASD Park, HM Kang… - Journal of the …, 2015 - journals.lww.com
Genome-wide association studies (GWASs) have identified multiple loci associated with the
risk of CKD. Almost all risk variants are localized to the noncoding region of the genome; …

Integrated functional genomic analysis enables annotation of kidney genome-wide association study loci

KB Sieber, A Batorsky, K Siebenthall… - Journal of the …, 2019 - journals.lww.com
Background Linking genetic risk loci identified by genome-wide association studies (GWAS)
to their causal genes remains a major challenge. Disease-associated genetic variants are …

Chromatin conformation links distal target genes to CKD loci

MM Brandt, CA Meddens… - Journal of the …, 2018 - journals.lww.com
Genome-wide association studies (GWASs) have identified many genetic risk factors for
CKD. However, linking common variants to genes that are causal for CKD etiology remains …

[PDF][PDF] Genetic-variation-driven gene-expression changes highlight genes with important functions for kidney disease

YA Ko, H Yi, C Qiu, S Huang, J Park, N Ledo… - The American Journal of …, 2017 - cell.com
Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to
10% of the US population. Genome-wide association studies (GWASs) have identified …

[HTML][HTML] Genome-wide association studies of CKD and related traits

A Tin, A Köttgen - Clinical Journal of the American Society of …, 2020 - journals.lww.com
The past few years have seen major advances in genome-wide association studies (GWAS)
of CKD and kidney function–related traits in several areas: increases in sample size from> …

Integrative biology identifies shared transcriptional networks in CKD

S Martini, V Nair, BJ Keller, F Eichinger… - Journal of the …, 2014 - journals.lww.com
A previous meta-analysis of genome-wide association data by the Cohorts for Heart and
Aging Research in Genomic Epidemiology and CKDGen consortia identified 16 loci …

A catalog of genetic loci associated with kidney function from analyses of a million individuals

M Wuttke, Y Li, M Li, KB Sieber, MF Feitosa, M Gorski… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms

KM Sullivan, K Susztak - Nature Reviews Nephrology, 2020 - nature.com
Genome-wide association studies (GWAS) have identified hundreds of loci associated with
kidney-related traits such as glomerular filtration rate, albuminuria, hypertension, electrolyte …

Genetic and epigenetic factors influencing chronic kidney disease

LJ Smyth, S Duffy, AP Maxwell… - American Journal of …, 2014 - journals.physiology.org
Chronic kidney disease (CKD) has become a serious public health problem because of its
associated morbidity, premature mortality, and attendant healthcare costs. The rising …

Insights into kidney diseases from genome-wide association studies

M Wuttke, A Köttgen - Nature Reviews Nephrology, 2016 - nature.com
Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …