Studies with fluoroquinolones have led to a general method for restricting the selection of
antibiotic-resistant mutants. The strategy is based on the use of antibiotic concentrations that …

The continuing escalation of antimicrobial resistant human pathogens and the limited
number of new antimicrobial agents under development has dictated that our knowledge on …

The selection of antibiotic-resistant mutant bacteria is proposed to occur in a drug
concentration range (the mutant selection window) that extends from the minimum inhibitory …

Antibiotic resistance is increasingly recognized as a serious global problem. The mutant
prevention concentration (MPC) is a novel concept1 that has been employed in the …

The mutant selection window hypothesis postulates that, for each antimicrobial-pathogen
combination, an antimicrobial concentration range exists in which selective amplification of …

This review summarizes key data illustrating the clinical importance of pharmacodynamics,
particularly among the fluoroquinolone family of antibacterials. Antibacterials are often …

Mutant prevention concentration (MPC) has been proposed as a new measure of antibiotic
potency by which the ability to restrict selection of resistant mutants is evaluated. To …

Abstract Pharmacokinetic/pharmacodynamic (PK/PD) parameters, such as the ratio of peak
to minimum inhibitory concentration (peak/MIC ratio), ratio of 24-hour area under the curve …

To obtain a general framework for understanding selection of antibiotic-resistant mutants,
allelic diversity was examined with about 600 fluoroquinolone-resistant mutants of …

Evolving antimicrobial resistance is of global concern. The impact of decreased
susceptibility to current antibacterials coupled with the decline in the marketing of new …