Background The parasympathetic nervous system, whose main neural substrate is the
vagus nerve, exerts a fundamental antinociceptive role and influences gastrointestinal …

This study was designed to investigate whether transcutaneous auricular vagal nerve
stimulation (taVNS) would be able to improve major pathophysiologies of functional …

The vagus nerve (VN) is a key element of the autonomic nervous system. As a mixed nerve,
the VN contributes to the bidirectional interactions between the brain and the gut, ie, the …

Metabolic feedback between the gut and the brain relayed via the vagus nerve contributes to
energy homeostasis. We investigated in healthy adults whether non-invasive stimulation of …

Implanted vagus nerve stimulation (VNS) for obesity was recently approved by the FDA.
However, its efficacy and mechanisms of action remain unclear. Herein, we synthesize …

Activation of the vagal afferents by noxious gastrointestinal stimuli suggests that vagal
afferents may play a complex role in visceral pain processes. The contribution of the vagus …

Vagal nerve stimulation is a promising method for the treatment of pain. The aim was to
investigate the effect of non-invasive transcutaneous vagal nerve stimulation (TVNS) on the …

BACKGROUND: Recent preclinical work strongly suggests that vagus nerve stimulation
efficiently modulates nociception and pain processing in humans. Most recently, a medical …

The vagus nerve is a central component of cholinergic anti‐inflammatory pathways. We
sought to evaluate the effect of bilateral transcutaneous cervical vagal nerve stimulation (t …

Background Abdominal pain and constipation are 2 main symptoms in patients with
constipation-predominant irritable bowel syndrome (IBS-C). This study aimed to investigate …