In plants, animals, and fungi, members of the Dicer family of RNase III-related enzymes
process double-stranded RNA (dsRNA) to initiate small-RNA-mediated gene-silencing …

Dicer is a ribonuclease III-like enzyme playing a key role in the RNA silencing pathway.
Genome sequencing projects have demonstrated that eukaryotic genomes vary in the …

The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …

RNA interference (RNAi) is a post-transcriptional silencing process, triggered by double-
stranded RNA (dsRNA), leading to the destabilization of homologous mRNAs. A distinction …

Small regulatory RNAs are key regulators of gene expression. One class of small regulatory
RNAs, termed the endogenous small interfering RNAs (endo siRNAs), is thought to …

In organisms ranging from Arabidopsis to humans, Dicer requires dsRNA-binding proteins
(dsRBPs) to carry out its roles in RNA interference (RNAi) and micro-RNA (miRNA) …

Double-stranded RNA-binding proteins (dsRBPs), such as R2D2 and Loquacious (Loqs),
function in tandem with Dicer (Dcr) enzymes in RNA interference (RNAi). In Drosophila, Dcr …

Small RNAs have several important biological functions. MicroRNAs (miRNAs) and trans-
acting small interfering RNAs (tasiRNAs) regulate mRNA stability and translation, and …

Formation of microRNA (miRNA) requires an RNaseIII domain-containing protein, termed
DICER-1 in animals and DICER-LIKE1 (DCL1) in plants, to catalyze processing of an RNA …

Dicer, a double-stranded RNA (dsRNA)-specific endoribonuclease, plays an essential role
in triggering both transcriptional and post-transcriptional gene silencing in eukaryotes by …