The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …
dependent gene-environment interactions that require analysis as a dynamic process in a …
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
A Nebel, R Kleindorp, A Caliebe, M Nothnagel… - Mechanisms of ageing …, 2011 - Elsevier
We conducted a case–control genome-wide association study (GWAS) of human longevity,
comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 …
comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 …
ApoE gene and exceptional longevity: insights from three independent cohorts
The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its
influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine …
influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine …
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
JM Murabito, R Yuan, KL Lunetta - Journals of Gerontology …, 2012 - academic.oup.com
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …
the identification of the underlying genes remains a challenge. Longevity is a complex …
APOE distribution in world populations with new data from India and the UK
PP Singh, M Singh, SS Mastana - Annals of human biology, 2006 - Taylor & Francis
Background: The APOE gene and its protein product is associated with a number of plasma
proteins like very-low density lipoprotein (VLDL), high density lipoprotein (HDL) …
proteins like very-low density lipoprotein (VLDL), high density lipoprotein (HDL) …
The genetics of the human APOE polymorphism
The genetic origin of the three common variants of the human apolipoprotein E (apoE)
protein, known as E2, E3 and E4, was understood in 1981, and since the mid 1980s these …
protein, known as E2, E3 and E4, was understood in 1981, and since the mid 1980s these …
APOE Alleles and Extreme Human Longevity
P Sebastiani, A Gurinovich, M Nygaard… - The Journals of …, 2019 - academic.oup.com
We assembled a collection of 28,297 participants from seven studies of longevity and
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …
identifying genes associated with longer lives. To identify such longevity alleles, we …
Aging and cardiovascular diseases: The role of gene–diet interactions
D Corella, JM Ordovas - Ageing research reviews, 2014 - Elsevier
In the study of longevity, increasing importance is being placed on the concept of healthy
aging rather than considering the total number of years lived. Although the concept of …
aging rather than considering the total number of years lived. Although the concept of …