Novel genetic loci underlying human intracranial volume identified through genome-wide association

HHH Adams, DP Hibar, V Chouraki, JL Stein… - Nature …, 2016 - nature.com
Intracranial volume reflects the maximally attained brain size during development, and
remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes …

Common variants at 6q22 and 17q21 are associated with intracranial volume

Nature genetics, 2012 - nature.com
During aging, intracranial volume remains unchanged and represents maximally attained
brain size, while various interacting biological phenomena lead to brain volume loss …

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …

B Zhao, T Luo, T Li, Y Li, J Zhang, Y Shan, X Wang… - Nature …, 2019 - nature.com
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …

Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

PR Jansen, M Nagel, K Watanabe, Y Wei… - Nature …, 2020 - nature.com
The phenotypic correlation between human intelligence and brain volume (BV) is
considerable (r≈ 0.40), and has been shown to be due to shared genetic factors. To further …

Common variants at 12q15 and 12q24 are associated with infant head circumference

HR Taal, B St Pourcain, E Thiering, S Das… - Nature …, 2012 - nature.com
To identify genetic variants associated with head circumference in infancy, we performed a
meta-analysis of seven genome-wide association studies (GWAS)(N= 10,768 individuals of …

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

E Hofer, GV Roshchupkin, HHH Adams, MJ Knol… - Nature …, 2020 - nature.com
Cortical thickness, surface area and volumes vary with age and cognitive function, and in
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …

Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes

V Warrier, EM Stauffer, QQ Huang, EM Wigdor… - Nature …, 2023 - nature.com
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …

Normative brain size variation and brain shape diversity in humans

PK Reardon, J Seidlitz, S Vandekar, S Liu, R Patel… - Science, 2018 - science.org
Brain size variation over primate evolution and human development is associated with shifts
in the proportions of different brain regions. Individual brain size can vary almost twofold …

Heritability of regional brain volumes in large-scale neuroimaging and genetic studies

B Zhao, JG Ibrahim, Y Li, T Li, Y Wang, Y Shan… - Cerebral …, 2019 - academic.oup.com
Brain genetics is an active research area. The degree to which genetic variants impact
variations in brain structure and function remains largely unknown. We examined the …

Common genetic variants influence human subcortical brain structures

DP Hibar, JL Stein, ME Renteria, A Arias-Vasquez… - Nature, 2015 - nature.com
The highly complex structure of the human brain is strongly shaped by genetic influences.
Subcortical brain regions form circuits with cortical areas to coordinate movement, learning …