In vitro ultrasound-mediated leakage from phospholipid vesicles

M Pong, S Umchid, AJ Guarino, PA Lewin, J Litniewski… - Ultrasonics, 2006 - Elsevier
Interest in using ultrasound energy in wound management and intracellular drug delivery
has been growing rapidly. Development and treatment optimization of such non-diagnostic …

Non-invasive assessment and control of ultrasound-mediated membrane permeabilization

J Liu, TN Lewis, MR Prausnitz - Pharmaceutical research, 1998 - Springer
Purpose. Ultrasound has been shown to transiently permeabilize biological membranes,
thereby facilitating delivery of large compounds such as proteins and DNA into cells and …

Ultrasound-mediated disruption of cell membranes. I. Quantification of molecular uptake and cell viability

HR Guzman, DX Nguyen, S Khan… - The Journal of the …, 2001 - pubs.aip.org
Ultrasound-mediated drug delivery is a nonchemical, nonviral, and noninvasive method for
targeted transport of drugs and genes into cells. Molecules can be delivered into cells when …

Factors affecting responsivity of unilamellar liposomes to 20 kHz ultrasound

HY Lin, JL Thomas - Langmuir, 2004 - ACS Publications
Ultrasound is commonly used in the preparation of unilamellar liposome dispersions and is
often considered for cell membrane disruption for drug delivery or DNA transfection …

Mechanism of intracellular delivery by acoustic cavitation

RK Schlicher, H Radhakrishna, TP Tolentino… - Ultrasound in medicine …, 2006 - Elsevier
Using conditions different from conventional medical imaging or laboratory cell lysis,
ultrasound has recently been shown to reversibly increase plasma membrane permeability …

Microstreaming inside model cells induced by ultrasound and microbubbles

V Pereno, J Lei, D Carugo, E Stride - Langmuir, 2020 - ACS Publications
Studies on the bioeffects produced by ultrasound and microbubbles have focused primarily
on transport in bulk tissue, drug uptake by individual cells, and disruption of biological …

Over-pressure suppresses ultrasonic-induced drug uptake

SB Stringham, MA Viskovska, ES Richardson… - Ultrasound in medicine …, 2009 - Elsevier
Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer
tissues. The present study further examines the role of acoustic cavitation in US-induced …

Ultrasound-mediated disruption of cell membranes. II. Heterogeneous effects on cells

HR Guzman, DX Nguyen, S Khan… - The Journal of the …, 2001 - pubs.aip.org
Ultrasound has been shown to reversibly and irreversibly disrupt membranes of viable cells
through a mechanism believed to involve cavitation. Because cavitation is both temporally …

Ultrasonic drug delivery–a general review

WG Pitt, GA Husseini, BJ Staples - Expert opinion on drug delivery, 2004 - Taylor & Francis
Ultrasound has an ever-increasing role in the delivery of therapeutic agents, including
genetic material, protein and chemotherapeutic agents. Cavitating gas bodies, such as …

Duration of ultrasound-mediated enhanced plasma membrane permeability

B Lammertink, R Deckers, G Storm, C Moonen… - International journal of …, 2015 - Elsevier
Ultrasound (US) induced cavitation can be used to enhance the intracellular delivery of
drugs by transiently increasing the cell membrane permeability. The duration of this …