Mega‐analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group

A Zugman, A Harrewijn, EM Cardinale… - Human Brain …, 2022 - Wiley Online Library
The ENIGMA group on Generalized Anxiety Disorder (ENIGMA‐Anxiety/GAD) is part of a
broader effort to investigate anxiety disorders using imaging and genetic data across …

ENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders

JM Bas‐Hoogendam, NA Groenewold… - Human Brain …, 2022 - Wiley Online Library
Anxiety disorders are highly prevalent and disabling but seem particularly tractable to
investigation with translational neuroscience methodologies. Neuroimaging has informed …

Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group

A Harrewijn, EM Cardinale, NA Groenewold… - Translational …, 2021 - nature.com
The goal of this study was to compare brain structure between individuals with generalized
anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent …

Two decades of anxiety neuroimaging research: new insights and a look to the future

AJ Shackman, AS Fox - American Journal of Psychiatry, 2021 - Am Psychiatric Assoc
Anxiety is widely conceptualized as a state of heightened distress, arousal, and vigilance
that can be elicited by potential threat (1, 2). When extreme or pervasive, anxiety can be …

Toward robust anxiety biomarkers: a machine learning approach in a large-scale sample

EA Boeke, AJ Holmes, EA Phelps - Biological Psychiatry: Cognitive …, 2020 - Elsevier
Background The field of psychiatry has long sought biomarkers that can objectively
diagnose patients, predict treatment response, or identify individuals at risk of illness onset …

Pilot multimodal twin imaging study of generalized anxiety disorder

JM Hettema, B Kettenmann, V Ahluwalia… - Depression and …, 2012 - Wiley Online Library
Background Generalized anxiety disorder (GAD) is a common chronic condition that is
relatively understudied compared to other psychiatric syndromes. Neuroimaging studies …

[HTML][HTML] Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review

D Madonna, G Delvecchio, JC Soares… - Brazilian Journal of …, 2019 - SciELO Brasil
Objectives: Brain imaging studies carried out in patients suffering from generalized anxiety
disorder (GAD) have contributed to better characterize the pathophysiological mechanisms …

Biological markers of generalized anxiety disorder

E Maron, D Nutt - Dialogues in clinical neuroscience, 2017 - Taylor & Francis
Generalized anxiety disorder (GAD) is a prevalent and highly disabling mental health
condition; however, there is still much to learn with regard to pertinent biomarkers, as well as …

Current status of brain imaging in anxiety disorders

C Damsa, M Kosel, J Moussally - Current opinion in psychiatry, 2009 - journals.lww.com
Brain imaging research in anxiety disorders has become increasingly important, especially
in the last decade, because of the opportunity to validate neurobiological hypotheses for …

A review of neuroimaging studies in generalized anxiety disorder:“So where do we stand?”

B Goossen, J van der Starre… - Journal of Neural …, 2019 - Springer
Generalized anxiety disorder (GAD) is a prevalent anxiety disorder, but is still poorly
recognized in clinical practice. The aim of this review is to provide a coherent understanding …