Efficacy and safety of molnupiravir for the treatment of non-hospitalized adults with mild COVID-19: a randomized, open-label, parallel-group phase 3 trial

SK Tippabhotla, DS Lahiri, C Kandi - 2022 - papers.ssrn.com
Background: Molnupiravir is an oral prodrug with antiviral activity against severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2). Molnupiravir was initially developed for …

[HTML][HTML] Efficacy and safety of molnupiravir in mild COVID-19 patients in India

S Sinha, N Kumarasamy, VK Suram, SS Chary, S Naik… - Cureus, 2022 - ncbi.nlm.nih.gov
Background At the peak of the coronavirus disease 2019 (COVID-19) pandemic, the need
for an orally administered agent to prevent the progression of acute respiratory syndrome …

Phase 2/3 trial of molnupiravir for treatment of Covid-19 in nonhospitalized adults

Y Caraco, GE Crofoot, PA Moncada… - NEJM …, 2022 - evidence.nejm.org
Background Safe and effective oral treatments are needed to improve clinical outcomes for
nonhospitalized patients with Covid-19. Molnupiravir is an orally administered, small …

Molnupiravir—a novel oral anti-SARS-CoV-2 agent

CC Lee, CC Hsieh, WC Ko - Antibiotics, 2021 - mdpi.com
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
rapidly resulted in a global pandemic with approximately 4 million deaths. Effective oral …

Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis

JJ Malin, S Weibel, H Gruell… - Journal of …, 2023 - academic.oup.com
Background The role of molnupiravir for coronavirus disease 2019 (COVID-19) treatment is
unclear. Methods We conducted a systematic review until 1 November 2022 searching for …

Molnupiravir for the treatment of COVID-19 in immunocompromised participants: efficacy, safety, and virology results from the phase 3 randomized, placebo-controlled …

MG Johnson, JM Strizki, ML Brown, H Wan… - Infection, 2023 - Springer
Purpose Immunocompromised patients have a potentially increased risk for progression to
severe COVID-19 and prolonged replication of SARS-CoV-2. This post hoc analysis …

Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

SH Khoo, R Fitzgerald, T Fletcher… - Journal of …, 2021 - academic.oup.com
Objectives AGILE is a Phase Ib/IIa platform for rapidly evaluating COVID-19 treatments. In
this trial (NCT04746183) we evaluated the safety and optimal dose of molnupiravir in …

What impact can molnupiravir have on the treatment of SARS-CoV-2 infection?

F Kayali, MST Leung, W Wong… - Expert Opinion on …, 2022 - Taylor & Francis
The coronavirus disease (COVID-19) pandemic, caused by the spread of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), marked its debut in 2019. To date, this …

What will be the role of molnupiravir in the treatment of COVID-19 infection?

A Vitiello, V Troiano, R La Porta - Drugs & Therapy Perspectives, 2021 - Springer
The global COVID-19 pandemic is currently underway. To date, there are approximately
4.55 million deaths and 219 million people infected [1]. The massive vaccination campaign …

Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients

A Jayk Bernal, MM Gomes da Silva… - … England Journal of …, 2022 - Mass Medical Soc
Background New treatments are needed to reduce the risk of progression of coronavirus
disease 2019 (Covid-19). Molnupiravir is an oral, small-molecule antiviral prodrug that is …