IL-27 derived from macrophages facilitates IL-15 production and T cell maintenance following allergic hypersensitivity responses
J Suwanpradid, MJ Lee, P Hoang, J Kwock… - Frontiers in …, 2021 - frontiersin.org
Crosstalk between T cells, dendritic cells, and macrophages in temporal leukocyte clusters
within barrier tissues provides a new concept for T cell activation in the skin. Activated T cells …
within barrier tissues provides a new concept for T cell activation in the skin. Activated T cells …
IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes
M Wittmann, J Zeitvogel, D Wang, T Werfel - Journal of allergy and clinical …, 2009 - Elsevier
BACKGROUND: IL-27 is produced by antigen-presenting cells early during immune
responses. IL-27 has been described to support T-cell polarization along the TH1 lineage …
responses. IL-27 has been described to support T-cell polarization along the TH1 lineage …
IL-25 enhances TH17 cell–mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells
H Suto, A Nambu, H Morita, S Yamaguchi… - Journal of Allergy and …, 2018 - Elsevier
Background In addition to thymic stromal lymphopoietin and IL-33, IL-25 is known to induce
TH 2 cytokine production by various cell types, including TH 2 cells, TH 9 cells, invariant …
TH 2 cytokine production by various cell types, including TH 2 cells, TH 9 cells, invariant …
IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes
D Pennino, K Eyerich, C Scarponi… - The Journal of …, 2010 - journals.aai.org
Th17 is a newly identified lineage of effector T cells involved in autoimmunity and immune
responses to pathogens. We demonstrate in this study the pathogenic role of IL-17 …
responses to pathogens. We demonstrate in this study the pathogenic role of IL-17 …
[HTML][HTML] IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions
S Shibata, Y Tada, Y Asano, K Yanaba… - Journal of Investigative …, 2013 - Elsevier
IL-27, a member of the IL-12 cytokine family, primes Th1 cell differentiation, whereas it
suppresses Th17 cell development. We have previously reported that serum IL-27 levels are …
suppresses Th17 cell development. We have previously reported that serum IL-27 levels are …
[HTML][HTML] ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation
JM Leyva-Castillo, C Galand, S Mashiko… - Journal of Allergy and …, 2020 - Elsevier
Background Atopic dermatitis skin lesions demonstrate increased expression of IL-25 by
keratinocytes and increased numbers of type 2 innate lymphoid cells (ILC2s) that express …
keratinocytes and increased numbers of type 2 innate lymphoid cells (ILC2s) that express …
IL-27 regulates IL-18 binding protein in skin resident cells
M Wittmann, R Doble, M Bachmann, J Pfeilschifter… - PLoS …, 2012 - journals.plos.org
IL-18 is an important mediator involved in chronic inflammatory conditions such as
cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL …
cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL …
IL-27 regulates cytokine production as a double-edged sword in keratinocytes
A Aioi, T Imamichi - Trends in Immunotherapy, 2022 - systems.enpress-publisher.com
Inflammaging is a subject of considerable attention, because aging is characterized by low-
grade, chronic, and asymptomatic inflammation, concomitant with increased blood levels of …
grade, chronic, and asymptomatic inflammation, concomitant with increased blood levels of …
[引用][C] Skin Innate Lymphoid Cells Type 2 Activated by Keratinocyte-derived IL-25 promote IL-13-mediated skin allergic inflammation
JM Leyva-Castillo, RS Geha - Journal of Allergy and Clinical …, 2018 - jacionline.org
Methods Wild type (WT) mice, Il17rb-/-mice, Il13-/-mice and mice which selectively lack IL-
25R in ILC2s or IL-25 in keratinocytes were epicutaneously (EC) sensitized on tape stripped …
25R in ILC2s or IL-25 in keratinocytes were epicutaneously (EC) sensitized on tape stripped …
[引用][C] 014 IL-27 induces IL-15 production to facilitate T cell survival in allergic contact dermatitis
J Suwanpradid, M Lee, P Hoang, J Kwock… - Journal of Investigative …, 2020 - Elsevier