Aberrations in post-translational modifications of histones have been shown to occur in
cancer cells but only at individual promoters; they have not been related to clinical outcome …

PURPOSE Epigenetic alterations such as DNA methylation and histone modifications play
important roles in carcinogenesis. It was reported that global histone modification patterns …

INTRODUCTION Cancer arises from clonal expansion of a single cell. Yet, most human
cancers are characterized by extensive intratumor heterogeneity and comprise various …

Cancer cells exhibit alterations in histone modification patterns at individual genes and
globally at the level of single nuclei in individual cells. We demonstrated previously that …

Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer,
characterized by the presence of inactivating mutations in the VHL gene in most cases,, and …

Prostate cancer is the second most common cause of male cancer deaths in the United
States. However, the full range of prostate cancer genomic alterations is incompletely …

Histones are characterized by numerous posttranslational modifications that influence gene
transcription,. However, because of the lack of global distribution data in higher eukaryotic …

Histones package DNA, and post-translational modifications of histones can regulate access
to DNA. Until recently, histone methylation—unlike all other histone modifications—was …

Prostate cancer is the most frequently diagnosed cancer in American men,. Screening for
prostate-specific antigen (PSA) has led to earlier detection of prostate cancer, but elevated …

The linker histone H1 is believed to be involved in chromatin organization by stabilizing
higher-order chromatin structure,,. Histone H1 is generally viewed as a repressor of …