BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice
CYD Lee, AJ De La Rocha, K Inouye, P Langfelder… - bioRxiv, 2023 - biorxiv.org
Background Genetic study of late-onset Alzheimer's disease (AD) reveals that a rare
Arginine-to-Histamine mutation at amino acid residue 47 (R47H) in Triggering Receptor …
Arginine-to-Histamine mutation at amino acid residue 47 (R47H) in Triggering Receptor …
[HTML][HTML] Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer's disease models
Variants of TREM2 are associated with Alzheimer's disease (AD). To study whether
increasing TREM2 gene dosage could modify the disease pathogenesis, we developed …
increasing TREM2 gene dosage could modify the disease pathogenesis, we developed …
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia
TREM2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for
Alzheimer's disease (AD). As microglial responses modulated by TREM2 are central to AD …
Alzheimer's disease (AD). As microglial responses modulated by TREM2 are central to AD …
[HTML][HTML] Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
Background The rare p. H157Y variant of TREM2 (Triggering Receptor Expressed on
Myeloid Cells 2) was found to increase Alzheimer's disease (AD) risk. This mutation is …
Myeloid Cells 2) was found to increase Alzheimer's disease (AD) risk. This mutation is …
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
TR Jay, CM Miller, PJ Cheng, LC Graham… - Journal of Experimental …, 2015 - rupress.org
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for
Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types …
Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types …
ASO-mediated Trem2 lowering reduces amyloid pathology in mice
A Le Bras - Lab Animal, 2021 - nature.com
In the past 10 years, large scale genetic studies have linked TREM2 variants to Alzheimer's
disease (AD). The discovery of TREM2 risk variants has prompted extensive research to …
disease (AD). The discovery of TREM2 risk variants has prompted extensive research to …
[HTML][HTML] Established beta amyloid pathology is unaffected by TREM2 elevation in reactive microglia in an Alzheimer's disease mouse model
Several genetic studies have identified a rare variant of triggering receptor expressed on
myeloid cells 2 (TREM2) as a risk factor for Alzheimer's disease (AD). However, findings on …
myeloid cells 2 (TREM2) as a risk factor for Alzheimer's disease (AD). However, findings on …
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model
TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2
impairs ligand binding and increases Alzheimer's disease (AD) risk. In mouse models of …
impairs ligand binding and increases Alzheimer's disease (AD) risk. In mouse models of …
[HTML][HTML] The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
Abstract Background The R47H variant of the Triggering Receptor Expressed on Myeloid
cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease. Mouse …
cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease. Mouse …
[HTML][HTML] The emerging roles and therapeutic potential of soluble TREM2 in Alzheimer's disease
L Zhong, XF Chen - Frontiers in aging neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia characterized by the
deposition of extracellular amyloid-β (Aβ)-containing plaques, the formation of intraneuronal …
deposition of extracellular amyloid-β (Aβ)-containing plaques, the formation of intraneuronal …