Coumarins behave as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
with a mechanism of inhibition distinct from other classes of inhibitors. A series of 7 …

A series of coumarins and benzocoumarins incorporating methyl and hydroxyl moieties in
the heterocyclic ring were investigated for the inhibition of the zinc enzyme carbonic …

A series of coumarins incorporating hydroxy-, chloro-and/or chloromethyl-moieties in
positions 3-, 4-, 6-and 7-of the heterocyclic ring were investigated for the inhibition of the …

A series of coumarins incorporating tert-butyl-dimethylsilyloxy-or allyoxy-moieties in
positions 4-, 6 or 7 of the heterocyclic ring have been synthesized and then converted to the …

Sulfocoumarins behave as interesting inhibitors of the metalloenzyme carbonic anhydrase
(CA, EC 4.2. 1.1). Here, we report a new series of 7-substituted derivatives which were …

Coumarins were recently shown to constitute a novel class of mechanism-based carbonic
anhydrase (CA, EC 4.2. 1.1) inhibitors. We demonstrate that sulfocoumarins (1, 2 …

Aim: Human carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are validated
antitumor/antimetastatic drug and tumor imaging targets with sulfonamide inhibitors and …

Two series of disubstituted coumarins incorporating ether and acetyl/propionyl moieties in
positions 6, 7-and 7, 8-of the heterocyclic ring were synthesized investigated for the …

We have carried out the design, synthesis, and evaluation of a small library of 2-
aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and …

Abstract Benzoxepinones (“homocoumarins”) are identified as a new class of selective
inhibitors for tumor associated human carbonic anhydrases (hCA, EC 4.2. 1.1) isoforms IX …