Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

F Bianchini, V Crivelli, ME Abernathy, C Guerra… - Science …, 2023 - science.org
Emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued …

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

SJ Zost, P Gilchuk, RE Chen, JB Case, JX Reidy… - Nature medicine, 2020 - nature.com
Antibodies are a principal determinant of immunity for most RNA viruses and have promise
to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 …

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif

Y Fang, P Sun, X Xie, M Du, F Du, J Ye… - Science …, 2022 - science.org
The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
such as the Omicron variants that are highly transmissible and immune evasive …

Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

V Dussupt, RS Sankhala, L Mendez-Rivera… - Nature …, 2021 - nature.com
Prevention of viral escape and increased coverage against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal …

Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein

S Xu, Y Wang, Y Wang, C Zhang, Q Hong… - Emerging Microbes & …, 2022 - Taylor & Francis
The emergence of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern threatens the efficacy of currently approved vaccines and authorized …

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Y Chen, X Zhao, H Zhou, H Zhu, S Jiang… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

LA VanBlargan, LJ Adams, Z Liu, RE Chen, P Gilchuk… - Immunity, 2021 - cell.com
With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased transmissibility and potential resistance, antibodies and vaccines …

Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking

L Liu, RG Casner, Y Guo, Q Wang, S Iketani, JFW Chan… - Immunity, 2023 - cell.com
SARS-CoV-2 continues to evolve, with many variants evading clinically authorized
antibodies. To isolate monoclonal antibodies (mAbs) with broadly neutralizing capacities …

Cross-neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike

S Changrob, Y Fu, JJ Guthmiller, PJ Halfmann, L Li… - Mbio, 2021 - Am Soc Microbiol
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …