Towards in silico oncology: adapting a four dimensional nephroblastoma treatment model to a clinical trial case based on multi-method sensitivity analysis
In the past decades a great progress in cancer research has been made although medical
treatment is still widely based on empirically established protocols which have many …
treatment is still widely based on empirically established protocols which have many …
'In silico'oncology for clinical decision making in the context of nephroblastoma
The present paper outlines the initial version of the ACGT (Advancing Clinico-Genomic
Trials)–an Integrated Project, partly funded by the EC (FP6-2005-IST-026996) I …
Trials)–an Integrated Project, partly funded by the EC (FP6-2005-IST-026996) I …
[HTML][HTML] Exploiting clinical trial data drastically narrows the window of possible solutions to the problem of clinical adaptation of a multiscale cancer model
The development of computational models for simulating tumor growth and response to
treatment has gained significant momentum during the last few decades. At the dawn of the …
treatment has gained significant momentum during the last few decades. At the dawn of the …
The" Oncosimulator": a multilevel, clinically oriented simulation system of tumor growth and organism response to therapeutic schemes. Towards the clinical …
The" Oncosimulator" is at the same time a concept of multilevel integrative cancer and
(treatment affected) normal tissue biology, an algorithmic construct and a software tool which …
(treatment affected) normal tissue biology, an algorithmic construct and a software tool which …
Mathematical models of cancer
M Patel, S Nagl - Cancer bioinformatics: from therapy design to …, 2006 - Wiley Online Library
Modelling and simulation are indispensable for the study of biological systems as dynamical
ensembles, made up of a large number of interacting components and exhibiting complex …
ensembles, made up of a large number of interacting components and exhibiting complex …
The technologically integrated oncosimulator: combining multiscale cancer modeling with information technology in the in silico oncology context
This paper outlines the major components and function of the technologically integrated
oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer …
oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer …
In silico oncology: exploiting clinical studies to clinically adapt and validate multiscale oncosimulators
GS Stamatakos, E Kolokotroni… - 2013 35th Annual …, 2013 - ieeexplore.ieee.org
This paper presents a brief outline of the notion and the system of oncosimulator in
conjunction with a high level description of the basics of its core multiscale model simulating …
conjunction with a high level description of the basics of its core multiscale model simulating …
Some mathematical modelling challenges and approaches in cancer
PK Maini, RA Gatenby - Cancer bioinformatics: from therapy …, 2006 - Wiley Online Library
Over the past several decades an intense, primarily experimental, scientific effort has
yielded remarkable increases in our understanding of tumour biology. In 2003 alone over …
yielded remarkable increases in our understanding of tumour biology. In 2003 alone over …
[HTML][HTML] In silico mathematical modelling for glioblastoma: a critical review and a patient-specific case
Glioblastoma extensively infiltrates the brain; despite surgery and aggressive therapies, the
prognosis is poor. A multidisciplinary approach combining mathematical, clinical and …
prognosis is poor. A multidisciplinary approach combining mathematical, clinical and …
In Silico Experimental Modeling of Cancer Treatment
Trisilowati, DG Mallet - International Scholarly Research …, 2012 - Wiley Online Library
In silico experimental modeling of cancer involves combining findings from biological
literature with computer‐based models of biological systems in order to conduct …
literature with computer‐based models of biological systems in order to conduct …