QT prolongation is associated with increased risk of cardiac arrhythmias. Identifying the
genetic variants that mediate antipsychotic-induced prolongation may help to minimize this …

QTc interval prolongation is one of the most common antipsychotic-induced side effects
which could lead to ventricular tachycardia or Torsade de Pointes, even cardiac arrest …

Administration of certain drugs (for example, antiarrhythmics, antihistamines, antibiotics,
antipsychotics) may occasionally affect myocardial repolarization and cause prolongation of …

Several antipsychotics and antidepressants have been associated with electrocardiogram
alterations, the most clinically relevant of which is the heart rate-corrected QT interval (QT c) …

Antipsychotics are effective in treating schizophrenia but may lead to a higher
cardiovascular risk due to QTc prolongation. Besides drugs, genetic and clinical factors may …

QT prolongation is a heart rhythm condition that impacts the lives of many people and when
severe can be life-threatening. QT prolongation has been linked to variations in several …

A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden
cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for …

Variability in response to drug use is common and heritable, suggesting that genome-wide
pharmacogenomics studies may help explain the 'missing heritability'of complex traits. Here …

Background: Drug-induced QT interval prolongation, a risk factor for life-threatening
ventricular arrhythmias, is a potential side effect of many marketed and withdrawn …

Long-QT syndrome (LQTS) is a congenital or drug-induced change in electrical activity of
the heart that can lead to fatal arrhythmias. Mutations in 12 genes encoding ion channels …