This study evaluated the efficacy of cationic nanoparticle (leciplex) to deliver carvedilol to
ocular surface for glaucoma treatment as recent studies pointed out the effect of topical …

Purpose:: We prepared and characterized topical ophthalmic formulations containing
brimonidine-loaded bioadhesive cationic chitosan or anionic alginate nanoparticles (NPs) …

Many effective anti-glaucoma drugs available for the treatment of ocular hypertension and
open angle glaucoma are associated with rapid and extensive precorneal loss caused by …

Purpose To assess the potential of chitosan (CS) nanoparticles for ocular drug delivery by
investigating their intraocular retention by γ-scintigraphy and intraocular pressure reduction …

Background Majorly, the reason for the permanent loss of vision is glaucoma. But the
currently available common treatment methodologies such as eye drops have various …

Brimonidine tartrate (BRT) is a water-soluble anti-glaucoma drug that is available in
ophthalmic solution (Alphagan Z®). Various ocular barriers prevent permeation and …

Background To date, the rapid clearance from ocular surface has been a huge obstacle for
using eye drops to treat glaucoma, since it has led to the short preocular residence time and …

The objective of the current study was to fabricate a thermosensitive in situ gelling system for
the ocular delivery of carvedilol-loaded spanlastics (CRV-SPLs). In situ gel formulations …

Purposes: The present study aimed to develop brimonidine tartrate loaded poly (lactic-co-
glycolic acid) acid vitamin E-tocopheryl polyethylene glycol 1000 succinate (BRT-PLGA …

Purpose Preparation of topical ophthalmic formulations containing brimonidine-loaded
nanoparticles prepared from various biodegradable polymers—PCL, PLA and PLGA—for …