Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects
Background With the increasing use of nanomaterials, the need for methods and assays to
examine their immunosafety is becoming urgent, in particular for nanomaterials that are …
examine their immunosafety is becoming urgent, in particular for nanomaterials that are …
Assessing the Immunosafety of Engineered Nanoparticles with a Novel in Vitro Model Based on Human Primary Monocytes
The possibility that nanomaterials could perturb the normal course of an inflammatory
response is a key issue when assessing nanoimmunosafety. The alteration of the normal …
response is a key issue when assessing nanoimmunosafety. The alteration of the normal …
Immunological properties of engineered nanomaterials
MA Dobrovolskaia, SE McNeil - Nature nanotechnology, 2007 - nature.com
Most research on the toxicology of nanomaterials has focused on the effects of nanoparticles
that enter the body accidentally. There has been much less research on the toxicology of …
that enter the body accidentally. There has been much less research on the toxicology of …
Interactions of nanomaterials with the immune system
S Hussain, JAJ Vanoirbeek… - Wiley Interdisciplinary …, 2012 - Wiley Online Library
Abstract Evaluation of the immunomodulatory potentials of nanomaterials is essential for
developing safe and consumer‐friendly nanotechnology. Various nanomaterials interact …
developing safe and consumer‐friendly nanotechnology. Various nanomaterials interact …
The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events
T Pfaller, R Colognato, I Nelissen, F Favilli… - …, 2010 - Taylor & Francis
Suitable assays and test strategies are needed to analyze potential genotoxic and
immunotoxic health effects caused by nanoparticle exposure. The development and …
immunotoxic health effects caused by nanoparticle exposure. The development and …
Cytokines as biomarkers of nanoparticle immunotoxicity
M Elsabahy, KL Wooley - Chemical Society Reviews, 2013 - pubs.rsc.org
Nanoscale objects, whether of biologic origin or synthetically created, are being developed
into devices for a variety of bionanotechnology diagnostic and pharmaceutical applications …
into devices for a variety of bionanotechnology diagnostic and pharmaceutical applications …
Immunotoxicity of nanomaterials in health and disease: Current challenges and emerging approaches for identifying immune modifiers in susceptible populations
Nanosafety assessment has experienced an intense era of research during the past
decades driven by a vivid interest of regulators, industry, and society. Toxicological assays …
decades driven by a vivid interest of regulators, industry, and society. Toxicological assays …
Immunosuppressive and anti‐inflammatory properties of engineered nanomaterials
AN Ilinskaya, MA Dobrovolskaia - British journal of …, 2014 - Wiley Online Library
Nanoparticle interactions with various components of the immune system are determined by
their physicochemical properties such as size, charge, hydrophobicity and shape …
their physicochemical properties such as size, charge, hydrophobicity and shape …
Are nanomaterials a threat to the immune system?
Nanoparticles can enter into the human body through several routes and interact with
components of the immune system. This interaction leads to enhanced release of different …
components of the immune system. This interaction leads to enhanced release of different …
Value of phagocyte function screening for immunotoxicity of nanoparticles in vivo
E Fröhlich - International journal of nanomedicine, 2015 - Taylor & Francis
Nanoparticles (NPs) present in the environment and in consumer products can cause
immunotoxic effects. The immune system is very complex, and in vivo studies are the gold …
immunotoxic effects. The immune system is very complex, and in vivo studies are the gold …