The objective of this investigation was to determine the role of secretory and cytosolic
isoforms of phospholipase A 2 (PLA 2) in the induction of arachidonic acid (AA) and …

Activation of group IV cytosolic phospholipase A 2 (gIV-PLA 2) is the essential first step in
the synthesis of inflammatory eicosanoids and in integrin-mediated adhesion of leukocytes …

Human eosinophils perform several functions dependent on phospholipase A2 (PLA2)
activity, most notably the synthesis of platelet-activating factor (PAF) and leukotriene C4 …

Kinases mediating phosphorylation and activation of cytosolic phospholipase A 2 (cPLA 2)
in intact cells remain to be fully characterized. Platelet-activating factor stimulation of human …

We previously reported that exogenously added human group V phospholipase A 2 (hVPLA
2) could elicit leukotriene B 4 biosynthesis in human neutrophils through the activation of …

We examined the regulatory role of cytosolic phospholipase A2 (cPLA2) and
phosphatidylinositol (PI)-specific phospholipase C (PLC) in the degranulation of human …

Background: Human basophils secrete leukotriene C4 (LTC4) in response to various stimuli,
and a short treatment with IL-3 enhances LTC4 release, although IL-3 alone does not induce …

Background Phospholipase A 2 s mediate the rate-limiting step in the formation of
eicosanoids such as cysteinyl leukotrienes (CysLTs). Group IVA cytosolic PLA 2 α (cPLA 2 …

We examined the role of p38, p42, and p44 mitogen-activated protein kinase (MAPK)
isoforms and cytosolic phospholipase A 2 (cPLA 2) activation in human eosinophil adhesion …

Secretory phospholipases A 2 (sPLA 2 s) are released in large amounts in the blood of
patients with systemic inflammatory diseases and accumulate at sites of chronic …