The MLKL channel in necroptosis is an octamer formed by tetramers in a dyadic process
Oligomerization of the mixed-lineage kinase domain-like protein (MLKL) is essential for its
cation channel function in necroptosis. Here we show that the MLKL channel is an octamer …
cation channel function in necroptosis. Here we show that the MLKL channel is an octamer …
Insane in the membrane: a structural perspective of MLKL function in necroptosis
EJ Petrie, JM Hildebrand… - Immunology and cell …, 2017 - Wiley Online Library
Necroptosis (or 'programmed necrosis') is a caspase‐independent cell death pathway that
operates downstream of death receptors, including Tumour Necrosis Factor Receptor‐1 …
operates downstream of death receptors, including Tumour Necrosis Factor Receptor‐1 …
MLKL forms cation channels
B Xia, S Fang, X Chen, H Hu, P Chen, H Wang, Z Gao - Cell research, 2016 - nature.com
The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-
induced necroptosis. Recent studies on necroptosis execution revealed a commitment role …
induced necroptosis. Recent studies on necroptosis execution revealed a commitment role …
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
Y Dondelinger, W Declercq, S Montessuit, R Roelandt… - Cell reports, 2014 - cell.com
Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and
crucial protein for necroptosis induction, how MLKL transduces the death signal remains …
crucial protein for necroptosis induction, how MLKL transduces the death signal remains …
Evolutionary divergence of the necroptosis effector MLKL
MC Tanzer, I Matti, JM Hildebrand, SN Young… - Cell Death & …, 2016 - nature.com
The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal
obligatory component of the necroptosis cell death pathway known. Phosphorylation of the …
obligatory component of the necroptosis cell death pathway known. Phosphorylation of the …
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Necroptotic cell death is mediated by the most terminal known effector of the pathway,
MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by …
MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by …
[HTML][HTML] MLKL, the protein that mediates necroptosis, also regulates endosomal trafficking and extracellular vesicle generation
Activation of the pseudokinase mixed lineage kinase domain-like (MLKL) upon its
phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed cell …
phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed cell …
A plug release mechanism for membrane permeation by MLKL
MLKL is crucial for necroptosis, permeabilizing membranes through its N-terminal region
upon phosphorylation of its kinase-like domain by RIP3. However, the mechanism …
upon phosphorylation of its kinase-like domain by RIP3. However, the mechanism …
Necrosome core machinery: MLKL
J Zhang, Y Yang, W He, L Sun - Cellular and Molecular Life Sciences, 2016 - Springer
In the study of regulated cell death, the rapidly expanding field of regulated necrosis, in
particular necroptosis, has been drawing much attention. The signaling of necroptosis …
particular necroptosis, has been drawing much attention. The signaling of necroptosis …
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis
Mixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent
form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine …
form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine …