Measures to quantify changes in the pace of biological aging in response to intervention are
needed to evaluate geroprotective interventions for humans. We used data from the …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Methods to quantify biological aging are emerging as new measurement tools for
epidemiology and population science and have been proposed as surrogate measures for …

Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …

Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …

Aging is a physiological process and represents one of the major risk factors for various
human diseases, such as cancer, cardiovascular diseases and most neurodegenerative …

It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …

Abstract Background Three DNA methylation (DNAm) based algorithms, DNAm PhenoAge
acceleration (AgeAccelPheno), DNAm GrimAge acceleration (AgeAccelGrim), and mortality …

Patterns of DNA methylation (DNAm) that track with aging have been identified. However,
the relevance of these patterns for aging outcomes remains unclear. Longitudinal …

Background Previous studies have shown that three DNA methylation (DNAm) based
algorithms of aging, DNAm PhenoAge acceleration (AgeAccelPheno), DNAm GrimAge …