An increasing number of studies document the presence of protein kinases facing outwards
at the cell surface of a diverse array of cells. These ecto-protein kinases phosphorylate cell …

Ecto‑protein kinases, including protein kinase CK2 (former name, casein kinase 2), have
been the focus of research for more than 30 years. At the beginning of the ecto‑kinase …

Mining of the literature and high-throughput mass spectrometry data from both healthy and
diseased tissues and from body fluids reveals evidence that various extracellular proteins …

The mitogen-activated protein (MAP) kinase extracellular-signal-regulated kinases (ERKs)
are activated by diverse mechanisms. These include ligation of receptor tyrosine kinases …

Eukaryotic elongation factor 2 kinase (eEF2K) is an atypical member of the α-kinase family,
and shows no sequence similarity to classical protein kinases. The identification of eEF2K …

The extracellular signal-regulated kinase (ERK) cascade is a central intracellular signaling
pathway that is activated by a variety of extracellular stimuli, and thereby regulates cellular …

Etk, the 70-kDa member of the Tec family of nonreceptor protein tyrosine kinases, is
expressed in a variety of hematopoietic, epithelial, and endothelial cells and was shown to …

Protein kinases have emerged as attractive targets for treatment of several diseases
prompting large-scale phosphoproteomics studies to elucidate their cellular actions and the …

We have developed a method of general application for identifying putative substrates of
protein kinases in cell extracts. Using this procedure, we identified the physiological …

Epithelial–mesenchymal transition (EMT) is a reversible cellular process, characterized by
changes in gene expression and activation of proteins, favoring the trans-differentiation of …