Modulation of TNF release by choline requires α7 subunit nicotinic acetylcholine receptor-mediated signaling

WR Parrish, M Rosas-Ballina, M Gallowitsch-Puerta… - Molecular …, 2008 - Springer
The α7 subunit-containing nicotinic acetylcholine receptor (α7nAChR) is an essential
component in the vagus nerve-based cholinergic anti-inflammatory pathway that regulates …

Stimulation of α7 cholinergic receptors inhibits lipopolysaccharide-induced neutrophil recruitment by a tumor necrosis factor α-independent mechanism

IAJ Giebelen, DJ van Westerloo, GJ LaRosa… - Shock, 2007 - journals.lww.com
The cholinergic nervous system controls inflammation by inhibiting the release of
proinflammatory cytokines such as tumor necrosis factor (TNF) α from lipopolysaccharide …

The role of α7nAChR-mediated cholinergic anti-inflammatory pathway in immune cells

Y Wu, L Wang, C Ji, S Gu, Q Yin, J Zuo - Inflammation, 2021 - Springer
Alpha 7 nicotinic acetylcholine receptor (α7nAChR) is widely distributed in the nervous and
non-cholinergic immune systems. It is necessary for the cholinergic transmitter to participate …

[HTML][HTML] The protective effect of alpha 7 nicotinic acetylcholine receptor activation on critical illness and its mechanism

REN Chao, Y Tong, J Li, Z Lu, Y Yao - International journal of …, 2017 - ncbi.nlm.nih.gov
Critical illnesses and injuries are recognized as major threats to human health, and they are
usually accompanied by uncontrolled inflammation and dysfunction of immune response …

[HTML][HTML] Cholinergic modulation of inflammation

VA Pavlov - International journal of clinical and experimental …, 2008 - ncbi.nlm.nih.gov
Recent studies have demonstrated that cytokine levels and inflammation can be regulated
by specifically augmenting cholinergic signaling via the efferent vagus nerve and the α7 …

Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of …

K Tsoyi, HJ Jang, JW Kim, HK Chang… - Antioxidants & redox …, 2011 - liebertpub.com
Activation of nicotinic acetylcholine receptor alpha7 subunit (α7nAChR) by nicotine leads to
the improved survival rate in experimental model of sepsis. Previously, we demonstrated …

Requisite role of the cholinergic α7 nicotinic acetylcholine receptor pathway in suppressing gram-negative sepsis-induced acute lung inflammatory injury

X Su, MA Matthay, AB Malik - The journal of immunology, 2010 - journals.aai.org
Although activation of the α7 nicotinic acetylcholine receptor (α7 nAChR) modulates the
response to sepsis, the role of this pathway in the development of sepsis-induced acute lung …

Acute lung injury is reduced by the α7nAChR agonist PNU‐282987 through changes in the macrophage profile

NM Pinheiro, FPR Santana, RR Almeida… - The FASEB …, 2017 - Wiley Online Library
Nicotinic α‐7 acetylcholine receptor (nAChRα7) is a critical regulator of cholinergic anti‐
inflammatory actions in several diseases, including acute respiratory distress syndrome …

α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex

PS Olofsson, DA Katz, M Rosas-Ballina, YA Levine… - Molecular …, 2012 - Springer
The immune response to infection or injury coordinates host defense and tissue repair, but
also has the capacity to damage host tissues. Recent advances in understanding protective …

Local stimulation of α7 cholinergic receptors inhibits LPS-induced TNF-α release in the mouse lung

IAJ Giebelen, DJ van Westerloo, GJ LaRosa… - Shock, 2007 - journals.lww.com
The cholinergic nervous system can inhibit the release of proinflammatory cytokines such as
TNF-α from LPS-stimulated macrophages. Acetylcholine, the principal neurotransmitter of …