Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the
best known environmental risk factors for chronic traumatic encephalopathy and Alzheimer's …

Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and
associated with the development of chronic traumatic encephalopathy (CTE) and …

Alzheimer disease (AD) and chronic traumatic encephalopathy (CTE) share a common
neuropathologic signature—neurofibrillary tangles made of phosphorylated tau—but do not …

Traumatic brain injury (TBI) is a serious problem that affects millions of people in the United
States alone. Multiple concussions or even a single moderate to severe TBI can also …

In Alzheimer's disease (AD) and other tauopathies, the tau protein forms fibrils, which are
believed to be neurotoxic. However, fibrillar tau has been dissociated from neuron death …

Tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD), are
neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports …

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is
associated with repetitive head impacts or exposure to blast waves. First described as punch …

Abstract Development of tau-based therapies for Alzheimer's disease requires an
understanding of the timing of disease-related changes in tau. We quantified the …

Amyloid-β (Aβ) toxicity in Alzheimer's disease (AD) is considered to be mediated by
phosphorylated tau protein. In contrast, we found that, at least in early disease, site-specific …

Traumatic brain injury (TBI) is a major environmental risk factor for subsequent development
of Alzheimer disease (AD). Pathological features that are common to AD and many …