Oxidative stress markers as well as high concentrations of copper are found in the vicinity of
Aβ amyloid deposits in Alzheimer's disease. The neurotoxicity of Aβ in cell culture has been …

Considerable evidence is mounting that dyshomeostasis of the redox‐active biometals, Cu
and Fe, and oxidative stress contribute to the neuropathology of Alzheimer's disease (AD) …

Aβ binds Zn 2+, Cu 2+, and Fe 3+ in vitro, and these metals are markedly elevated in the
neocortex and especially enriched in amyloid plaque deposits of individuals with …

Oxidative stress plays a key role in Alzheimer's disease (AD). In addition, the abnormally
high Cu2+ ion concentrations present in senile plaques has provoked a substantial interest …

Oxidative stress markers characterize the neuropathology both of Alzheimer's disease and
of amyloid-bearing transgenic mice. The neurotoxicity of amyloid Aβ peptides has been …

This chapter reviews transition metal ion dysregulation and oxidative stress in the
pathogenesis of Alzheimer's disease. It focuses on the roles of metal ions in …

Cu2+ ions are found concentrated within senile plaques of Alzheimer's disease patients
directly bound to amyloid-β peptide (Aβ) and are linked to the neurotoxicity and self …

The extracellular domain of transmembrane Aβ amyloid precursor protein (APP) has a Cu
(II) reducing activity upon Cu (II) binding associated with the formation of a new disulfide …

Although much maligned, the amyloid-β (Aβ) protein has been shown to possess a number
of trophic properties that emanate from the protein's ability to bind Cu, Fe and Zn. Aβ …

Alzheimer's disease is characterized by signs of a major oxidative stress in the neocortex
and the concomitant deposition of Amyloid beta (Aβ). Aβ is a metalloprotein that binds …